Clinical Trials Logo
  1. Home
  2. Myelomeningocele
  3. NCT00175123

Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele

Myelomeningocele Clinical Trial

Official title:
Phase 4 Study of the Effect of Botulinum-A Toxin Injected in Neurogenic Overactive Bladders of Children Born With Myelomeningocele

Clinical Trial Summary

The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders. The purpose of treating the bladder (with different drugs) is to prevent damage to the kidneys and renal function. The aim of this study is to compare a conventionally used drug (oxybutynin) with botulinum toxin. The hypothesis of the study is that botulinum toxin is equal to oxybutynin in the treatment of overactive bladder.

Clinical Trial Description

Neurogenic bladder is often seen in children with myelomeningocele, tumors in the spinal canal, or a traumatized spinal cord. The majority of the patients have high pressure bladders which can lead to reflux and frequent infections in the urinary tract. Although children experience insufficient bladder emptying, many of them also experience urinary incontinence and have to perform clean intermittent catheterization (CIC). If no intervention is made, the children are at high risk of renal deterioration. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00175123
Study type Interventional
Source University of Aarhus
Contact
Status Active, not recruiting
Phase Phase 4
Start date May 2005
Completion date June 2008
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06042140 - Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair N/A
Recruiting NCT03562286 - Open Spina Bifida Fetoscopic Repair Project N/A
Completed NCT04468568 - In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline
Recruiting NCT04362592 - In-Utero Endoscopic Correction of Spina Bifida N/A
Recruiting NCT03856034 - Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele N/A
Active, not recruiting NCT03936322 - Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida - A Pilot Study N/A
Not yet recruiting NCT06405698 - Role of Perforator Flaps in Back Defects Reconstruction N/A
Completed NCT02390895 - Prenatal Endoscopic Repair of Fetal Spina Bifida N/A
Active, not recruiting NCT03090633 - Fetoscopic Repair of Isolated Fetal Spina Bifida N/A
Not yet recruiting NCT03088761 - Cuff Pressure in Infants N/A
Active, not recruiting NCT04484441 - Maternal-fetal Immune Responses to Fetal Surgery
Recruiting NCT04738539 - Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
Recruiting NCT04652908 - Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial Phase 1/Phase 2
Terminated NCT02493062 - Evaluation of Hysterotomy Site After Open Fetal Surgery N/A
Completed NCT03550898 - Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele N/A
Active, not recruiting NCT04251806 - Sleep-disordered Breathing in Infants With Myelomeningocele
Terminated NCT02509377 - Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0 N/A
Recruiting NCT03788122 - Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery N/A
Completed NCT02664207 - Extended Criteria For Fetal Myelomeningocele Repair N/A
Recruiting NCT03315637 - Fetal Endoscopic Surgery for Spina Bifida N/A