Myeloma Clinical Trial
Official title:
Evaluation of Pomalidomide in Combination With High Dose Dexamethasone and Oral Cyclophosphamide in Patients With Relapsed and Refractory Myeloma
The main purpose of this study is to see whether pomalidomide can help people with myeloma. Researchers also want to find out if pomalidomide is safe and tolerable.
There are two parts to this study:
- The first part of this study (Phase 1) will determine a safe dose of the medication
cyclophosphamide in combination with pomalidomide and dexamethasone.
- Once the safest dose has been determined, this study (Phase 2) will look to see the
difference in effectiveness of pomalidomide in combination with high dose dexamethasone
with or without cyclophosphamide for the treatment of patients who have myeloma, which
has relapsed to or become refractory (not responding) to prior treatment.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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