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NCT04436029 Clinical Trial

Descartes-11 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy

Myeloma Multiple Clinical Trial

Official title:
Descartes-11 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04436029
Other study ID # DC 11B
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date June 12, 2020
Est. completion date March 10, 2022

Study information
Verified date March 2022
Source Cartesian Therapeutics
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-11 in patients with high-risk myeloma who have residual disease following induction therapy.

Recruitment information / eligibility
Status Completed
Enrollment 4
Est. completion date March 10, 2022
Est. primary completion date March 10, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients must be 18 years of age or older at the time of enrollment - High-risk multiple myeloma patients who complete pre-transplant induction treatment anti- myeloma drug combination (minimum 2 drugs). Exclusion Criteria: - Patients who are pregnant or lactating. - Patients who have any active and uncontrolled infection. No blood cultures are necessary unless clinically indicated.

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• Descartes 11
Car T-cells

Locations
Country Name City State
United States Center for Cancer and Blood Disorders Bethesda Maryland
United States Hackensack University Medical Center Hackensack New Jersey
United States Medical College of Wisconsin Madison Wisconsin
United States Stephenson Cancer Center Oklahoma University Health Science Centers Oklahoma City Oklahoma

Sponsors (1)
Lead Sponsor Collaborator
Cartesian Therapeutics

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Rate of stringent complete response 2 years
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