Myelofibrosis Clinical Trial
Official title:
Etude de l'efficacité et de la tolérance de l'interféron-pégylé Dans Les myélofibroses
Patients who carried primary or secondary myelofibrosis from Philadelphia negative MPNs
(PMF/SMF) and who are treated or are about to be treated with pegylated-interferon (mostly
α2a) are eligible to this prospective study. Biological and clinical parameters will be
collected from the beginning of the drug use until last news.
A non-opposition consent form need to be signed before entering this study.
In all centres interested, patients who were diagnosed for PMF/SMF can be treated with oral
or sub-cutaneous drugs in order to reduce clinical symptoms and biological abnormalities
belonging to these diseases.
Pegylated-interferon is one of the better weapons that can be used in these cases. These
treatments are well known and used from many years in french hematological centres.
The investigators to collect clinical and biological data from patients treated with
pegylated-interferon α2a (the most use) in case of PMF/SMF in order to assess efficacity and
tolerance to this drug. The prescription of the product and the dose are under the
responsibility of each practician.
Clinical data collected: disease and patients characteristics at the time of diagnosis and at
the beginning of the drug use, spleen and liver size, presence of constitutive symptoms,
transfusion needs.
Biological data collected: complete hemogram, CD34+ cells count, allele burden of JAK2V617F
and calreticulin clones if DNA samples are collected.
These data will be collected avery 3 months during the two first years and every 6 months
after.
The investigators also recorded adverse side effects if significative, the concomitant use of
hematological drugs (cytoreductive treatments, ASE...), modalities of prescription of the
drugs and the reason for stopping the drug and etiology of death if happened.
;
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