Myelodysplastic Syndromes Clinical Trial
Official title:
Pathogenesis of Acute Leukemia, Lymphoproliferative Disorders, and Myeloproliferative Disorders
| NCT number | NCT01728402 |
| Other study ID # | IRB00004422 |
| Secondary ID | 5R21CA159265 |
| Status | Enrolling by invitation |
| Phase | |
| First received | |
| Last updated | |
| Start date | September 2008 |
| Verified date | March 2024 |
| Source | OHSU Knight Cancer Institute |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
The cause of blood and bone marrow cancers is poorly understood; however, most research focuses on how cancer cells grow and develop. Because the causes of these cancers are unknown, current treatments may be unnecessarily harsh and often do not provide a cure. Identifying the causes of blood cancers would allow for the development of treatments that are more likely to provide a cure. To find the causes of blood and bone marrow cancers, we will look for specific cancer cell abnormalities that are responsible for cancer cell growth. We will then look to see if drugs that can reverse these abnormalities can kill cancer cells.
| Status | Enrolling by invitation |
| Enrollment | 5000 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 1 Year and older |
| Eligibility | Inclusion Criteria: - Suspected or confirmed diagnosis of AL, LPD, MDS, or MPD - Male or female of all ages - Willing and able to sign informed consent - Willing guardian consent for participants under 18 years of age Exclusion Criteria: - No suspected or confirmed diagnosis of acute leukemias (AL), lymphoproliferative disorders (LPD), myelodysplastic syndromes (MDS), or myeloproliferative diseases (MPD) |
| Country | Name | City | State |
|---|---|---|---|
| United States | OHSU Knight Cancer Institute | Portland | Oregon |
| Lead Sponsor | Collaborator |
|---|---|
| OHSU Knight Cancer Institute | National Cancer Institute (NCI), National Institutes of Health (NIH) |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Identify and determine the frequency of mutations causing aberrant signaling pathway function in patients with acute leukemias (AL), lymphoproliferative disorders (LPD), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN) | Integrated functional genomics studies (whole genome sequencing, RNAi, proteomics, drug sensitivity, expression profiling) will be used to identify aberrant signaling pathways that contribute to the formation of hematologic malignancies. | After laboratory analyses are complete. Lab samples are collected at the time of a scheduled blood draw, bone marrow procedure, tissue biopsy, or other visit for usual medical care |
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