Myelodysplastic Syndromes Clinical Trial
Official title:
Creation of Bone Marrow Microenvironment for Treatment of MDS in Conjunction With Allogeneic Stem Cell Transplantation
Normal bone marrow function depends on the coexistence of normal hematopoietic stem cells
and a microenvironment mostly located in the medullary part of the bones. Stem cells cannot
function properly in the absence of an adequate microenvironment. Whereas in malignant and
non-malignant hematologic diseases caused by a deficiency or abnormal stem cells, stem cell
transplantation is the treatment of choice that results in a cure, in diseases such as MDS,
myelofibrosis, and other conditions associated with an abnormal microenvironment,
pancytopenia may occur despite the presence of apparently normal hematopoietic cells with no
recognizable cytogenetic abnormality.
We, the investigators at Hadassah Medical Organization, proved in experimental studies that
the entire osteohematopoietic complex consisting of trabecular bone, hematopoietic
microenvironment (of stromal origin) and hematopoietic tissue has been successfully
transferred directly into ablated bone marrow cavity in a one-step transplantation
procedure.
The goal of this study is to enhance hematopoiesis in patients with myelofibrosis syndrome
by intraosseous inoculation of demineralized bone matrix (DBM) together with allogeneic bone
marrow cells (BMC).
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label
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