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Clinical Trial Summary

The goal of this clinical research study is to learn about the safety of giving immune cells called natural killer (NK) cells with chemotherapy to patients with leukemia, lymphoma, or multiple myeloma. Immune system cells (such as NK cells) are made by the body to attack foreign or cancerous cells. Researchers think that NK cells you receive from a donor may react against cancer cells in your body, which may help to control the disease.


Clinical Trial Description

Primary Objective: To determine the safety, efficacy and optimal cell dose of CAR.70/IL15-transduced CB-NK cells in patients with relapsed/refractory hematological malignances. The efficacy and optimal dose will be identified for individual diseases. Secondary Objectives: - To quantify persistence of infused allogeneic donor CAR-transduced CB-derived NK cells in the recipient. - To conduct comprehensive immune reconstitution studies. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05092451
Study type Interventional
Source M.D. Anderson Cancer Center
Contact David Marin
Phone (713) 792-4179
Email dmarin@mdanderson.org
Status Recruiting
Phase Phase 1/Phase 2
Start date November 1, 2022
Completion date August 31, 2026

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