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A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs

Myelodysplastic Syndrome (MDS) Clinical Trial

Official title:
A Pilot Study of CDX-301 (rhuFlt3L) With or Without Plerixafor for the Mobilization and Transplantation of Allogeneic Blood Cell Grafts in HLA-Matched Donor/Recipient Sibling Pairs

Clinical Trial Summary

This is an open-label, multicenter, prospective pilot study of CDX-301 with or without plerixafor as a stem cell mobilizer for allogeneic transplantation (stem cells that come from another person). HLA-matched sibling healthy volunteers (donors) and patients with protocol specified hematologic malignancies (recipients) will be enrolled.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Chronic Lymphocytic Leukemia (CLL)
  • Chronic Myelogenous Leukemia (CML)
  • For Donors
  • For Recipients
  • Hodgkin Disease
  • Hodgkins Disease (HD)
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Myeloid, Acute
  • Lymphoma, Non-Hodgkin
  • Myelodysplastic Syndrome (MDS)
  • Myelodysplastic Syndromes
  • Non-Hodgkins Lymphoma (NHL)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Preleukemia
  • Related Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling
Clinical Trial Details
NCT number NCT02200380
Study type Interventional
Source Celldex Therapeutics
Contact
Status Terminated
Phase Phase 2
Start date July 2014
Completion date April 13, 2016
View Details
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