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Myasthenia Gravis clinical trials

View clinical trials related to Myasthenia Gravis.

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NCT ID: NCT03468452 Completed - Clinical trials for Myasthenia Gravis Associated With Thymoma

Early Versus Late Extubation in Myasthenia Gravis Patients

Start date: January 1, 2015
Phase: N/A
Study type: Observational

MYASTHENIA GRAVIS (MG) is an autoimmune disease characterized by varying degrees of muscle weakness and fatigability worsened with exertion and relieved with rest。Thymectomy plays an important role in the management of these patients because a consistent association between myasthenic and thymic pathology has been recognized.The need for prolonged mechanical ventilation in these patients after thymectomy is determined by their preoperative condition and various perioperative risk factors. Leventhal et al proposed a preoperative scoring system to predict the need for postoperative mechanical ventilation in myasthenic patients undergoing thymectomy based on the following 4 criteria: duration of MG, chronic respiratory disease, dose of pyridostigmine, and vital capacity. However, some investigators discovered that the Leventhal criteria may not be the sole benchmark and that other criteria such as severity of myasthenia,history of myasthenic crisis, and presence of thymoma may be more important in predicting the necessity for prolonged mechanical ventilation after thymectomy. Naguib et al described multivariate determinants of the need for postoperative ventilation after thymectomy in MG patients predominantly on the basis of pulmonary function tests. In addition, the prevalence and presentation of MG may be variable among different ethnic groups. However, there are very few large studies investigating the determinants of prolonged mechanical ventilation after thymectomy. The authors describe the parameters associated with prolonged mechanical ventilation after trans-sternal thymectomy at their institution.

NCT ID: NCT03315130 Completed - Clinical trials for Generalized Myasthenia Gravis

Safety and Efficacy Study of RA101495 in Subjects With Generalized Myasthenia Gravis

Start date: October 11, 2017
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and efficacy of RA101495 in patients with generalized Myasthenia Gravis (gMG). Subjects will be randomized in a 1:1:1 ratio to receive daily SC doses of 0.1 mg/kg RA101495, 0.3 mg/kg RA101495, or matching placebo for 12 weeks.

NCT ID: NCT03304054 Completed - Clinical trials for Myasthenia Gravis, Generalized

Study to Evaluate Amifampridine Phosphate in Patients With MuSK-MG

Start date: April 18, 2018
Phase: Phase 3
Study type: Interventional

Efficacy and safety of amifampridine phosphate in improving the activities of daily living for patients with antibody positive MuSK myasthenia gravis.

NCT ID: NCT03205306 Completed - Myasthenia Gravis Clinical Trials

Myasthenia Gravis and Psyche

Start date: May 8, 2017
Phase:
Study type: Observational

The purpose of the study is to systematically capture and characterize mental comorbidities for patients with myasthenia gravis. Anxiety disorders and depression for example, can negatively affect the quality of life and lead to e.g. unemployment and early retirement especially in young patients. Additionally the researchers want to find out in what way certain aspects of the disease have an influence on the quality of life, and whether different concepts of coping with the disease have different effects on the quality of life for patients with myasthenia gravis. During the study, close relatives of patients will also be asked to provide input about their current stress situation in the context of supporting their relative. Based on the results, the investigators want to improve and supplement established treatment concepts, to ensure a more comprehensive and individual treatment.

NCT ID: NCT03165435 Withdrawn - Clinical trials for Myasthenia Gravis, Generalized

A Study to Evaluate the Efficacy of CV-MG01 (Myasterix) in Myasthenia Gravis

Start date: July 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Study CV-0003 will be the second clinical trial administering CV-MG01 in humans. This will be a phase 2/3 proof-of-efficacy therapeutic confirmatory study following the proof-of-concept exploratory phase 1 study (CV-0002).

NCT ID: NCT03059888 Terminated - Myasthenia Gravis Clinical Trials

Trial of Orencia in Patients With Myasthenia Gravis

Start date: April 12, 2017
Phase: Early Phase 1
Study type: Interventional

This pilot research study is being done to see if the drug abatacept (Orencia ®) will be helpful in treating patients with myasthenia gravis (MG) who do not respond satisfactorily to other drugs that are used to suppress the immune system. Abatacept has been successful in treating experimental MG in laboratory animals, and this study is to determine its effectiveness in patients with MG.

NCT ID: NCT03052751 Completed - Myasthenia Gravis Clinical Trials

Study to Test the Safety, Tolerability and Efficacy of UCB7665 in Subjects With Moderate to Severe Myasthenia Gravis

Start date: May 15, 2017
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the clinical efficacy of UCB7665 as a chronic-intermittent treatment in subjects with generalized myasthenia gravis (MG) who are classified as moderate to severe.

NCT ID: NCT03049956 Completed - Clinical trials for Myasthenia Gravis, Ocular

OVEMP in Myasthenia

Start date: November 1, 2016
Phase: N/A
Study type: Interventional

Myasthenia gravis is an autoimmune disorder of neuromuscular transmission, characterized by fluctuating muscle weakness and fatigability. In isolated ocular myasthenia, when only the extraocular muscles are involved, most common ancillary tests, such as acetylcholine receptor autoantibodies and repetitive nerve stimulation, are often negative. A simple, quick and non-invasive test for ocular myasthenia based on ocular vestibular evoked myogenic potentials (oVEMP) was recently developed. The main goal of the study is to validate repetitive oVEMP stimulation in a blinded diagnostic accuracy study in order to facilitate early and accurate diagnosis of ocular myasthenia.

NCT ID: NCT02965573 Completed - Myasthenia Gravis Clinical Trials

A Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness

Start date: December 30, 2016
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, multicenter Phase II study to evaluate the safety, efficacy, and pharmacokinetics of ARGX-113 for the treatment of autoimmune Myasthenia Gravis (MG) with generalized muscle weakness.

NCT ID: NCT02950155 Active, not recruiting - Clinical trials for Generalized Myasthenia Gravis

A Study Evaluating the Safety and Efficacy of Rituximab in Patients With Myasthenia Gravis

Rinomax
Start date: October 16, 2016
Phase: Phase 3
Study type: Interventional

A randomized, double-blind, placebo-controlled multicenter study evaluating the safety and efficacy of Rituximab (Mabthera®) in patients with new onset generalized myasthenia gravis (MG).