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Rituximab EfFicacy IN MyasthEnia Gravis (REFINE) — REFINE  

Myasthenia Gravis, Generalized Clinical Trial

Official title:
Single-cell Deep Phenotyping of B Lymphocytes to Personalize Immunotherapy in Patients With Myasthenia Gravis: Clinical Trial to Evaluate the Efficacy and Safety of Rituximab in Generalized AChR-antibody Positive Myasthenia Gravis

Clinical Trial Summary

The primary objective of this phase III trial is to investigate if Rituximab can reduce patients' functional impairment caused by MG. The secondary objectives of this trial are to assess whether treatment with rituximab in patients with MG will: - Allow faster and greater corticosteroid tapering - Reduce the frequency of exacerbations - Improve quality of life - Offer an acceptable safety and tolerability profile.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05868837
Study type Interventional
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Raffaele Iorio
Phone +393347185128
Email raffaele.iorio@policlinicogemelli.it
Status Recruiting
Phase Phase 3
Start date February 28, 2022
Completion date July 31, 2025
View Details
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