Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04759170
Other study ID # 186
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date August 30, 2020
Est. completion date December 27, 2021

Study information

Verified date April 2022
Source Ospedale di Circolo - Fondazione Macchi
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators have thought with a dedicated research group, to deepen the use of receptive music therapy so that it can improve the non-nutritive sucking of premature babies through listening to lullabies sung by parents and by the music therapist, which can reduce the use feeding tube and the negative effects on stress or growth of the newborn. The acquisition of oral skills and the achievement of a complete autonomous suction are of fundamental importance for the discharge of the preterm infant. Some studies published in the literature suggest that listening to the mother's voice and lullabies can represent a positive auditory stimulus for babies to support nutritional and non-nutritive sucking (NNS). Positive reinforcement is an effective development strategy for improving the feeding skills of preterm infants. A brief receptive music therapy intervention with the infant's personal pacifier that plays lullabies sung by both parents or by the music therapist could reduce the use of the feeding tube and the length of hospitalization. The possible negative effects of this stimulation on infant stress or growth remain to be explored. The aim of this study is not only to evaluate the benefits of positive reinforcement on the nutritional sucking competence of the premature baby, but at the same time also to observe the possible effects on his well-being and on his clinical stability.


Description:

In preterm infant, oral feeding requires significant maturation of the nervous system to support coordination of the oropharyngeal muscles and breathing. Additionally, the energy expenditure required by nutritional sucking attempts further complicates the acquisition of oral feeding skills and must be balanced by caloric intake to achieve sufficient growth. Achievement of exclusive autonomous sucking typically occurs only between 34 and 36 post-conception weeks. However, delays in achieving full oral sucking are common and may prolong the infant's hospitalization.Non-nutritive sucking (NNS) is a coordinated motor skill that can be taught through an educational activity that conditions neuronal responses through positive reinforcement.The international literature demonstrates that, through a behavioral approach, the use of the pacifier during non-nutritive sucking promotes nutritional sucking in preterm infants, improving their attachment and bottle feeding, and determines the reduction of the length of stay in intensive care. and improved general well-being of the newborn.The use of receptive music therapy can therefore be supportive and represent a positive reinforcement for the development and acquisition of oral and nutritional skills of the preterm infant. By taking advantage of non-nutritive sucking it is possible to improve the suckling capacity of the newborn, his feeding speed, weight gain and consequently reduce the length of hospital stay. It is essential to achieve this result without negatively affecting the well-being and stability of the preterm infant. Although musical studies in premature infants are limited, a 2014 study published in Pediatrics highlighted how music-specific and the maternal voice can positively reinforce the behavioral and neural responses of the preterm infant.On the other hand, the possible similar effects of reproduction, through the use of receptive music therapy of the song of the father and / or the music therapist, have not yet been investigated. The investigators therefore decided to design a prospective, randomized and controlled study to test the hypothesis that the parental (maternal and / or paternal) and / or music therapist's chant influences the well-being and / or stress of the newborn, evaluated through the parameter Heart Rate Variability (HRV), NNS development, nutritional sucking capacity, weight growth, and length of stay in premature infants compared to a control group of infants not subjected to sound stimulation . 40 premature babies will be recruited to be divided into 4 groups, after computerized randomization: n. 3 musical groups (mother song, father song, music therapist song) and 1 control group (not subjected to musical stimulation). Infants with gestational age at birth between the 23rd and 34th week of gestation will be included. Neonates with intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) may also be enrolled. Only newborns in ventilatory support at the time of evaluation and newborns with maxillofacial malformations that may interfere with the ability to suck will be excluded from enrollment. Newborns will be evaluated when they reach 32 ° -34 ° post-conception weeks, the amount of milk taken orally (by sucking) must be less than 50% of the total enteral intake.Infants who have not passed the subsequent hearing screening test using AABR (Brain Stem Automatic Response Test) will be excluded from the analysis, which is expected to be performed after reaching the correct age limit. OUTCOMES Positive reinforcement is an effective development strategy for improving the feeding skills of preterm infants. A short receptive music therapy intervention that reproduces lullabies sung by both parents or by the music therapist could positively influence the acquisition of nutritional skills and the growth of the preterm infant. Evaluating how this can affect the clinical stability of the newborn (and therefore on his state of stress, measured in terms of HRV) represents a fundamental and primary point to explore, in order to be able to make the possible use of receptive music therapy applicable in the strategy of positive reinforcement. The objective of this study is therefore to evaluate the tolerance of a receptive music therapy intervention (in terms of clinical stability, assessed through the HRV parameter) by the enrolled infants and to investigate any benefits of positive reinforcement obtained, through its use, on the acquisition of nutrition and growth skills of preterm infants. Primary outcomes: clinical stability by measuring Heart Rate Variability (HRV) • The primary objective of this study is to evaluate and monitor the tolerance of receptive music therapy (in terms of measurement of the clinical stability parameter HRV) by infants during music therapy treatment. Secondary outcomes: effects of positive reinforcement (carried out through the use of receptive music therapy) on the acquisition of food skills and the growth of preterm infants. In particular: - Evaluation of the achievement of exclusive oral sucking (determined as a week post-conception and / or days of life). - Evaluation of the variation in the speed of meal intake between the beginning and the end of the intervention (measured as the volume of the nutritional intake in milliliters divided by the time in minutes required for consumption). - Evaluation of the weight gain of the newborn in the 24 hours following stimulation - (expressed as a percentage of weight gain from enrollment). - Assessment of the growth rate from the last day of treatment to discharge. - Length of hospital stay.


Recruitment information / eligibility

Status Completed
Enrollment 40
Est. completion date December 27, 2021
Est. primary completion date February 10, 2021
Accepts healthy volunteers No
Gender All
Age group 23 Weeks to 34 Weeks
Eligibility Inclusion Criteria: - Infants with gestational age at birth between the 23rd and 34th week of gestation - Neonates with intraventricular hemorrhage (IVH) - Neonates with periventricular leukomalacia (PVL) Exclusion Criteria: - Only newborns in ventilatory support at the time of evaluation - Newborns with maxillofacial malformations - Newborns will be evaluated when they reach 32 ° -34 ° post-conception weeks, the amount of milk taken orally (by sucking) must be less than 50% of the total enteral intake - Infants who have not passed the next hearing screening test using AABR (Brain Stem Automatic Response Test), which is expected to be performed after reaching the correct age term

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Music therapy
The effects of receptive music therapy on oral nutrition and the well-being of the Italian premature baby

Locations

Country Name City State
Italy Ospedale F. Del Ponte Varese

Sponsors (1)

Lead Sponsor Collaborator
Ospedale di Circolo - Fondazione Macchi

Country where clinical trial is conducted

Italy, 

Outcome

Type Measure Description Time frame Safety issue
Other Length of hospital stay after music therapy treatment Length of hospital stay. through study completion, an average of 20 weeks
Primary Clinical stability by measuring Heart Rate Variability (HRV) Evaluate and monitor the tolerance of recorded receptive music therapy on clinical stability parameter HRV 8 day
Secondary Effects of positive reinforcement carried out through the use of recorded receptive music therapy Evaluation of the achievement of exclusive oral sucking through study completion, an average of 20 weeks
Secondary Effects of recorded receptive music therapy on positive reinforcement on the acquisition of food skills Evaluation of the variation in the speed of meal intake between the beginning and the end of the intervention. through study completion, an average of 20 weeks
Secondary Effects of the use of recorded receptive music therapy on the acquisition in skill of preterm infants. Evaluation of the weight gain of the newborn in the 24 hours following stimulation. through study completion, an average of 20 weeks
Secondary Effects of positive reinforcement carried out through the use of recorded receptive music therapy on the acquisition of food the growth of preterm infants. Assessment of the growth rate from the last day of treatment to discharge. through study completion, an average of 20 weeks
See also
  Status Clinical Trial Phase
Recruiting NCT04052074 - Complementary Therapy in Home Palliative Care Patients and Their Caregivers N/A
Recruiting NCT05603767 - Effects of Receptive Music Therapy Combined With Virtual Reality on Prevalent Symptoms in Patients With Advanced Cancer N/A
Completed NCT05038514 - The Effect of Music Therapy in COVID-19 Patients Given Prone Position N/A
Completed NCT04491110 - Intervention to Improve Quality of Sleep of Palliative Patient Carers in the Community: Clinical Trial N/A
Terminated NCT03604185 - Effects of Short-term Choir Participation on Auditory Perception in Hearing-aided Older Adults. N/A
Completed NCT04799574 - Effect of Music Therapy in Improving the Physical Fitness and Depression in the Frailty of the Community Elderly N/A
Recruiting NCT04602182 - Effectiveness of Musicotherapy in Weaning From Mechanical Ventilation N/A
Recruiting NCT05446662 - The Effect of Complementary Care Model on Patient Outcomes N/A
Not yet recruiting NCT05417711 - Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus N/A
Completed NCT04694508 - Intraoperative Music Therapy in Gynecological Oncology N/A
Enrolling by invitation NCT05744024 - Non-pharmacological Pain Care During Complex Wound Care Procedures N/A
Completed NCT05195307 - The Effect of Music Therapy Applied to Pregnant Women on Anxiety and Stress N/A
Completed NCT03429478 - Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery N/A
Completed NCT03916835 - MUSIDORE PED Study N/A
Completed NCT02363179 - Music in the Emergency Department (ED): Phase II N/A
Recruiting NCT05893485 - Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus N/A
Completed NCT05309369 - Musical Engagement of Brain LObes in Alzheimer's Disease Patients StudY N/A
Completed NCT05462977 - Rhythmically Entrained Exercise in Community-Dwelling Older Adults N/A
Recruiting NCT03280329 - Generalized Versus Personalized Music Therapy in the ICU to Reduce Sedation N/A
Completed NCT03147235 - The Effects of a Music Therapist Designed Listening Program on Intraoperative Vitrectomy N/A