Musculoskeletal Disorder Clinical Trial
Official title:
Changes in Quadriceps Muscular Activity in Patients After Total Knee Arthroplasty Compared to Healty Subjects
During Total Knee Arthroplasty (TKA), joint undergo considerable stress, which causes neuromuscular activation deficits of the quadriceps femoris muscle.The aim of the study is to investigate differences in quadriceps neuromuscular activity in the acute phase after surgery.
During Total Knee Arthroplasty (TKA), joint undergo considerable stress, which causes
neuromuscular activation deficits of the quadriceps femoris muscle. The current phenomenon
depends on a complex mechanism called Arthrogenic Muscle Inhibition (AMI). AMI has been
studied only in sub-acute and chronic phase after TKA due to the invasive procedures employed
in order to evaluate it; However, clinical observation and experimental studies suggest
presence of this phenomenon also in the first postoperative days. The aim of the study is to
investigate differences in quadriceps neuromuscular activity, in acute phase.
The study is a prospective observational study.15 healthy subjects and 15 patients scheduled
for TKA will be recruited. Patients will be asked to perform three isokinetic taks in the
same standardized biomechanical context in order to evaluate changes in quadriceps
neuromuscular activity after surgery as primary outcome. Secondly, correlation between
primary aim and pain perceived by the patient will be investigated. Moreover, patient's
functional ability will be assessed using the Timed Up and Go Test (TUG). Data will be
recorded the day before TKA, at one and three days after surgery.
At the end of data acquisition, normality and homogeneity of demographic variables will be
assessed. Differences in the outcome measures will be investigated with the t student test
(or with the related non-parametric tests) and by means of the mixed models repeated measures
ANOVA test. Linear regression will be applied to evaluate any correlation between outcomes.
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