Muscular Dystrophies Clinical Trial
Official title:
Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy - Angiotensin-Converting-Enzyme (ACE) Inhibitor Therapy
This trial intends to evaluate myocardial Fibrosis progression in Duchenne and Becker Muscular Dystrophy, as well the influence of ACE inhibitors in fibrosis progression. Additionally, this study aims to determine genetic predictors of cardiac involvement in these dystrophies.
Duchenne and Becker muscular dystrophies (DMD/BMD) are diseases characterized by progressive
skeletal muscle degeneration and replacement by fibrofatty tissue. Data on cardiac
involvement (defined as myocardial fibrosis), effect of ACE-inhibitors and specific genetic
mutations on myocardial involvement detected by cardiac magnetic resonance (CMR) is lacking.
The study will include 76 patients with DMD/BMD. All patients will be referred to two CMRs
for assessment of ventricular function and myocardial fibrosis. Patients with myocardial
fibrosis and normal left ventricle ejection fraction (LVEF) will be randomized into two
groups, each group receiving ACE-inhibitor treatment or no treatment for cardiomyopathy. A
genetic profile will be performed in every patient to identify possible mutations related to
cardiac involvement.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01480245 -
Open Label Study of GSK2402968 in Subjects With Duchenne Muscular Dystrophy
|
Phase 3 | |
| Completed |
NCT01153932 -
Phase II Doubleblind Exploratory Study of GSK2402968 in Ambulant Subjects With Duchenne Muscular Dystrophy
|
Phase 2 | |
| Completed |
NCT00027391 -
Study of Albuterol and Oxandrolone in Patients With Facioscapulohumeral Dystrophy (FSHD)
|
N/A | |
| Recruiting |
NCT04392518 -
Telerehabilitation in Proximal Muscle Weakness
|
N/A | |
| Completed |
NCT03851107 -
The Effectiveness of Participation-focused Interventions on Body Functions of Youth With Physical Disabilities
|
N/A | |
| Completed |
NCT01462292 -
A Clinical Study to Assess Two Doses of GSK2402968 in Subjects With Duchenne Muscular Dystrophy (DMD)
|
Phase 2 | |
| Recruiting |
NCT06094205 -
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
|
N/A | |
| Recruiting |
NCT05724173 -
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
|
N/A | |
| Recruiting |
NCT03698149 -
ECoG BMI for Motor and Speech Control
|
N/A | |
| Active, not recruiting |
NCT03811301 -
[BrainConnexion] - Neurodevice Phase I Trial
|
N/A | |
| Completed |
NCT05881122 -
Anti-inflammatory Diet Consultation for Those With Neuromuscular Disability
|
N/A | |
| Completed |
NCT04154098 -
Evaluation of a Textile Scapula Orthosis
|
N/A | |
| Recruiting |
NCT05409079 -
Schulze Muscular Dystrophy Ability Clinical Study
|
N/A | |
| Enrolling by invitation |
NCT04009408 -
Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders
|
N/A | |
| Active, not recruiting |
NCT00674843 -
The Efficacy of Using Far Infrared Radiation to Manage Muscular Dystrophies
|
Phase 1 | |
| Recruiting |
NCT02109692 -
Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies
|
N/A | |
| Active, not recruiting |
NCT04045158 -
Diaphragm Ultrasound in Neuromuscular Disorders
|
||
| Not yet recruiting |
NCT03508583 -
Turkish Version of The Measure of Processes of Care (MPOC)
|
||
| Terminated |
NCT01803412 -
A Study of the Safety, Tolerability & Efficacy of Long-term Administration of Drisapersen in US & Canadian Subjects
|
Phase 3 | |
| Completed |
NCT03406780 -
A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy
|
Phase 2 |