Clinical Trials Logo
  1. Home
  2. Muscular Dystrophies
  3. NCT01153932

Phase II Doubleblind Exploratory Study of GSK2402968 in Ambulant Subjects With Duchenne Muscular Dystrophy

Muscular Dystrophies Clinical Trial

Official title:
A Phase II, Double Blind, Exploratory, Parallel-group, Placebocontrolled Clinical Study to Assess Two Dosing Regimens of GSK2402968 for Efficacy, Safety, Tolerability and Pharmacokinetics in Ambulant Subjects With Duchenne Muscular Dystrophy

Clinical Trial Summary

The purpose of this study is to determine whether GSK2402968 given as a continuous dose and as an intermittent dose is effective and safe in the treatment of Duchenne muscular dystrophy.

Clinical Trial Description

This is a phase II, double-blind, exploratory, parallel-group, placebo-controlled clinical study in ambulant subjects with DMD resulting from a mutation that can be corrected by exon skipping induced by GSK2402968. The study aims to randomise 54 subjects. There will be 2 parallel cohorts. Each cohort will include subjects on GSK2402968 and matched placebo in a 2:1 ratio. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01153932
Study type Interventional
Source GlaxoSmithKline
Contact
Status Completed
Phase Phase 2
Start date September 2010
Completion date September 2012
View Details
See also
  Status Clinical Trial Phase
Terminated NCT01480245 - Open Label Study of GSK2402968 in Subjects With Duchenne Muscular Dystrophy Phase 3
Completed NCT00027391 - Study of Albuterol and Oxandrolone in Patients With Facioscapulohumeral Dystrophy (FSHD) N/A
Recruiting NCT04392518 - Telerehabilitation in Proximal Muscle Weakness N/A
Completed NCT03851107 - The Effectiveness of Participation-focused Interventions on Body Functions of Youth With Physical Disabilities N/A
Completed NCT01462292 - A Clinical Study to Assess Two Doses of GSK2402968 in Subjects With Duchenne Muscular Dystrophy (DMD) Phase 2
Recruiting NCT06094205 - Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) N/A
Recruiting NCT05724173 - Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia N/A
Recruiting NCT03698149 - ECoG BMI for Motor and Speech Control N/A
Active, not recruiting NCT03811301 - [BrainConnexion] - Neurodevice Phase I Trial N/A
Completed NCT05881122 - Anti-inflammatory Diet Consultation for Those With Neuromuscular Disability N/A
Completed NCT04154098 - Evaluation of a Textile Scapula Orthosis N/A
Recruiting NCT05409079 - Schulze Muscular Dystrophy Ability Clinical Study N/A
Enrolling by invitation NCT04009408 - Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders N/A
Active, not recruiting NCT00674843 - The Efficacy of Using Far Infrared Radiation to Manage Muscular Dystrophies Phase 1
Recruiting NCT02109692 - Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies N/A
Active, not recruiting NCT04045158 - Diaphragm Ultrasound in Neuromuscular Disorders
Not yet recruiting NCT03508583 - Turkish Version of The Measure of Processes of Care (MPOC)
Terminated NCT01803412 - A Study of the Safety, Tolerability & Efficacy of Long-term Administration of Drisapersen in US & Canadian Subjects Phase 3
Completed NCT03406780 - A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy Phase 2
Completed NCT01826487 - Phase 3 Study of Ataluren in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) Phase 3