Critically Ill Clinical Trial
Official title:
Substudy of Non-Seda Trial (NCT01967680): Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on Physical Function. An Investigator-initiated, Randomised, Clinical, Parallel-group, Multinational, Superiority Trial
Critically ill, ventilator-treated patients rapidly loose much of their muscle mass and
strength. This can attribute to prolonged admission, prolonged mechanical ventilation,
increased mortality and might have a negative impact on the physical function, degree of
independence and quality of life. The pathophysiological background for the loss of muscle
mass as well as possible effective treatment is still not well established. In the
NONSEDA-trial we randomise critically ill patients to non-sedation or sedation with a daily
wake-up trial during mechanical ventilation in the intensive care unit (ICU). It has never
been assessed whether non-sedation reduces the loss of muscle mass and strength.
Aim: To assess the effects of non-sedation versus sedation with a daily wake-up trial on
physical function after discharge from ICU.
Hypothesis: that non-sedation during ventilator-treatment will improve the physical function
after ICU-discharge, compared with standard treatment of sedation with a daily wake-up.
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