Clinical Trials Logo

Clinical Trial Summary

Creatine is a nutritional supplement that is often ingested to improve exercise performance. The advent of a new product that is applied to the skin overlying muscle offers potential benefit, if the creatine can be targeted to specific muscles. The investigators are testing a novel creatine cream to determine the effects on human muscular performance. The investigators are assessing whether 7 days of topical creatine application is additive to orally-ingested creatine for improving muscular power (determined by knee extension).

Clinical Trial Description

Creatine monohydrate is a popular nutritional supplement with athletes involved in sports involving strength and power. When creatine is orally ingested it combines with inorganic phosphate to form phorylcreatine (PCr) in skeletal muscle . Adenosine Triphosphate (ATP) is the immediate source of energy in muscle - during exercise ATP is broken down to Adenosine Diphosphate (ADP) and inorganic phosphate. Duration of high-intensity exercise is limited to a few seconds based on limited ATP stores in muscle. PCr acts to re-phosphorylate ADP to form ATP so that muscle contraction can continue at high intensities. After creatine monohydrate is ingested, high-intensity exercise capacity is increased because of the increased PCr stores in muscle.

Traditionally, creatine is consumed orally as a supplement. Delivra Inc. has developed a topical cream containing creatine that is designed to penetrate the skin. The study purpose is to determine whether topically-applied creatine is additive with orally-ingested creatine for improving muscular strength and power.

The hypothesis is that topically-applied creatine is additive with orally-ingested creatine for improving muscular performance.

The study involves a double-blind placebo-controlled parallel group design. Participants (n=132) will be randomized to receive either oral creatine supplementation or placebo (21 g/d) for 7 days. One leg of each participant will be randomized to receive topical creatine (3.5 mL/d) and the opposite leg placebo for 7 days.

The baseline assessment involves measuring muscular power during 5 sets of 15 repetitions of knee extension on a dynamometer, with each set separated by 1 minute rest, with each leg tested separately. Additional measures include assessment of body composition and body water content. Participants will then receive either oral creatine (21 g/d) or placebo for 7 days. One leg of each participant will be randomized to receive topical creatine (3.5 mL/d) and the opposite leg placebo for 7 days. The same assessments as done at baseline will then be repeated after the 7 days of creatine supplementation.

The primary outcomes are average and peak power output. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03006861
Study type Interventional
Source University of Saskatchewan
Status Completed
Phase N/A
Start date December 2016
Completion date October 2017

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT03297632 - Improving Muscle Strength, Mass and Physical Function in Older Adults N/A
Recruiting NCT04207359 - Effects of Creatine Supplementation in Breast Cancer Survivors N/A
Completed NCT04076982 - Effect of Supplementary Dietary Protein (21g Per Day) on Lean Mass and Strength in Sedentary, Adult Vegetarians N/A
Not yet recruiting NCT03662555 - Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function N/A
Completed NCT02530723 - Functional Changes and Power Training in Older Women. N/A
Completed NCT01704976 - SR-WBV Training for Frail Elderly in the Skilling up Stage N/A
Completed NCT01743495 - CAPABLE for Frail Dually Eligible Older Adults N/A
Completed NCT00183040 - HORMA: Hormonal Regulators of Muscle and Metabolism in Aging Phase 2
Completed NCT00060970 - Evaluating Muscle Function After Ankle Surgery N/A
Completed NCT04546048 - The Early Strength Training Program in Post-transplant Liver Cases N/A
Completed NCT03628365 - Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients? N/A
Completed NCT02739464 - Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients N/A
Completed NCT03600454 - The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response N/A
Recruiting NCT03301116 - Promoting Seniors' Health With Home Care Aides N/A
Completed NCT03258944 - Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters N/A
Recruiting NCT02778945 - Neuromuscular Blockade for Optimising Surgical Conditions During Spinal Surgery Phase 4
Terminated NCT03558841 - Effect of Lyra Gait Training on the Mobility of Geriatric Rehabilitation Inpatients N/A
Not yet recruiting NCT03675490 - ABLE (Arts-Based Exercise Enhancing LongEvity) N/A
Completed NCT02960425 - Delivra Topical Creatine for Improving Muscular Power N/A
Completed NCT02654886 - Safety and Effectiveness of Resistance Exercise Training in Patients With Pompe Disease. N/A