The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

Muscle Weakness Clinical Trial

Official title:

The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02434185
• Other study ID #: UCAM-BLD-1
• Status: Completed
• Start date: March 2015
• Est. completion date: April 2015

Study information

• Verified date: October 2018
• Source: Universidad Católica San Antonio de Murcia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

Description:

• 20 postmenopausal women unexperience in strength training or resistance training, without musculoskeletal, neurological diseases, and cardiovascular limiting-diseases were recruited.

• Maximum strength of lower limbs during leg-press exercise was measured for future analysis.

• The force-time curves were measured during climbing a step and rising from a chair.

• A fragility phenotype test was applied to the subjects to determine frailty phenotype classification, including; weight loss of greater than 10 lbs in the past 12 months, maximal handgrip strength, time to walk 15-ft at usual pace, self-reported leisure time physical activity, and self-reported exhaustion.

• The anthropometric measurements were performed by dual energy X-ray absorptiometry.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 2015
• Est. primary completion date: April 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• Postmenopausal women

Exclusion Criteria:

• Unexperienced in strength training or resistance training.

• Not musculoskeletal diseases.

• Not neurological diseases.

• Not cardiovascular limiting-diseases.

• Not fragility or pre-fragility phenotype.

Related Conditions & MeSH terms

• Muscle Weakness
• Paresis
• Postmenopausal Syndrome

Locations

Country	Name	City	State
Spain	Catholic University of Murcia	Murcia

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Católica San Antonio de Murcia

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assess the maximum force of lower limbs during bilateral and unilateral contraction		Screening visit
Primary	Assess the force-time curve during climbing a step		Screening visit
Primary	Assess the force-time curve during climbing rising from a chair		Screening visit
Primary	Assess bone mineral-free lean tissue mass by dual energy X-ray absorptiometry		Screening visit
Primary	Assess the fragility phenotype of the subjects		Screening visit
Primary	Assess the rate of force developed in time intervals (0-50, 50-100, 100-150ms) of lower limbs during bilateral and unilateral contraction		Screening visit
Primary	Assess fat-tissue mass and lean-tissue mass composition		Screening visit