The Impact of Quantitative Neuromuscular Monitoring in the PACU on

Status Completed

Clinical Trial Summary

Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications. NMBD-induced muscle weakness that lingers into the postoperative period, known as postoperative residual curarization (PORC), is present in as many as 40% of all patients that receive neuromuscular blocking agents. The Post Anesthesia Care Unit will be introducing monitoring as part of standard of care. This study will collect data about patients who receive NMBDs and examine the impact of monitoring on incidences of PORC.

Our study is designed to test the following hypotheses:

Hypothesis 1: The initiation of quantitative TOF monitoring as part of the standard PACU entry evaluation will change practitioner behavior in a manner that decreases the incidence of PORC in surgical patients at VUMC.

Hypothesis 2: The initiation of the routine TOF monitoring program will decrease the incidence of short- and long-term postoperative complications at VUMC.

Clinical Trial Description

Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications. NMBD-induced muscle weakness that lingers into the postoperative period, known as postoperative residual curarization (PORC), is present in as many as 40% of all patients that receive neuromuscular blocking agents. Physiological data suggest that PORC impairs normal respiratory function, and compelling evidence suggests PORC impairs clinical recovery in the immediate postoperative period and prolongs PACU length of stay. However, despite the widespread use of NMBDs and the frequent occurrence of PORC, limitations in the literature prevent an understanding of their full impact on clinical outcomes. This study will collect data about patients who receive NMBDs and examine the impact of monitoring on incidences of PORC.

The incidence of PORC and postoperative complications after the introduction of monitoring in the PACU will be determined by measuring TOF ratios and tracking the postoperative outcomes in the surgical patients over time. ;

Study Design

Related Conditions & MeSH terms

Muscle Weakness

Clinical Trial Details

NCT number	NCT01933841
Study type	Observational
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase
Start date	August 2016
Completion date	July 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05543980` - Leg Heat Therapy in Elderly Individuals	Phase 2
Enrolling by invitation	`NCT03297632` - Improving Muscle Strength, Mass and Physical Function in Older Adults	N/A
Completed	`NCT04207359` - Effects of Creatine Supplementation in Breast Cancer Survivors	N/A
Completed	`NCT06216015` - Exercise Training and Kidney Transplantation	N/A
Completed	`NCT04076982` - Effect of Supplementary Dietary Protein (21g Per Day) on Lean Mass and Strength in Sedentary, Adult Vegetarians	N/A
Not yet recruiting	`NCT03662555` - Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function	N/A
Completed	`NCT02530723` - Functional Changes and Power Training in Older Women.	N/A
Completed	`NCT01704976` - SR-WBV Training for Frail Elderly in the Skilling up Stage	N/A
Completed	`NCT01743495` - CAPABLE for Frail Dually Eligible Older Adults	N/A
Completed	`NCT00183040` - HORMA: Hormonal Regulators of Muscle and Metabolism in Aging	Phase 2
Enrolling by invitation	`NCT06432062` - Investigation the Effect of Rectus Abdominis and Erector Spinae Muscle Fatigue on the Viscoelastic Properties of Thoracolumbal Fascia
Recruiting	`NCT05073224` - Muscle Function After Childbirth	N/A
Completed	`NCT04956705` - Vitamin D and Calcium Supplementation at Danish Nursing Homes	N/A
Recruiting	`NCT03810768` - Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
Completed	`NCT00060970` - Evaluating Muscle Function After Ankle Surgery	N/A
Completed	`NCT04546048` - The Early Strength Training Program in Post-transplant Liver Cases	N/A
Completed	`NCT03628365` - Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?	N/A
Completed	`NCT05056298` - Effect of Insole Added to Exercise in Patients With Bilateral Flexible Flatfoot	N/A
Completed	`NCT02739464` - Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients	N/A
Completed	`NCT05497960` - Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms