Protein Supply in Elderly

Muscle Synthesis Clinical Trial

Official title:

Overnight Protein Supply as a Dietary Strategy to Improve Muscle Mass in Elderly.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01317511
• Other study ID #: MEC 09-3-078.3
• Status: Completed
• Phase: N/A
• First received: March 16, 2011
• Last updated: March 16, 2011
• Start date: June 2010
• Est. completion date: February 2011

Study information

• Verified date: March 2011
• Source: Maastricht University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
• Study type: Interventional

Clinical Trial Summary

Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to provide further insight into the responsiveness of the muscle protein synthetic machinery to food intake in relation to age.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: February 2011
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 65 Years to 80 Years

Eligibility

Inclusion Criteria:

• Males

• Age between 65 and 80 years

• BMI < 30 kg/m2

Exclusion Criteria:

• Type 2 diabetic patients

• Use of medication

• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. artrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis).

• Use of anticoagulants, blood diseases, allergy for lidocain.

• Contra indications for the use of a nasogastric tube: high risk of aspiration, gastric stasis, gastro-oesophageal reflux, upper gastrointestinal stricture, nasal injuries and base of skull fractures.

• Patients suffering from PKU (Phenylketonuria).

Study Design

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Muscle Synthesis

Intervention

Dietary Supplement:
• Protein
Protein drink

Locations

Country	Name	City	State
Netherlands	Maastricht University Medical Centre	Maastricht	Limburg

Sponsors (1)

Lead Sponsor	Collaborator
Maastricht University Medical Center

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Protein synthesis	Overnight protein synthesis	overnight (12 h)	No