Muscle Strength Clinical Trial
— LLSITOfficial title:
The Effect of Low-Load Resistance Training Versus High-intensity/Sprint Interval Training on Local Muscle Endurance, Mitochondrial Content, Mitochondrial Function, and Muscle Capillarization
Local muscle endurance (LME) is the ability of a muscle(s) to resist fatigue and is needed for daily activities of life such as climbing stairs, lifting/moving objects, and in sport contexts like rock climbing, mixed martial arts, cross-fit, kayaking and canoeing. Therefore, the investigators want learn how to improve LME and understand what in human bodies changes during exercise training to cause these changes. The investigators know that lifting weights improves muscle strength which is believed to improve LME. Specifically lifting less heavy weights (LLRET) for more repetitions leads to greater gains in LME opposed to heavier weights for fewer repetitions. Therefore, lifting less heavy weights likely causes greater changes in our muscles than lifting heavier weights that cause improvements in LME. Aerobic exercise preformed at high intensities in an interval format (HIIT) may also help improve LME by increasing our muscle's ability to produce energy during exercise. Therefore, the investigators want to see which of LLRET or HIIT leads to greater improvements in LME.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | October 2024 |
Est. primary completion date | August 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 19 Years to 30 Years |
Eligibility | Inclusion Criteria: 1. Able to understand and communicate in English 2. 19-30 years of age 3. All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate 4. Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., >2 hours per week of structured/periodized training) Exclusion Criteria: 1. BMI lower than 18 or greater than 30 2. Current use of cigarettes or other nicotine devices 3. Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders 4. Any medical condition impacting the ability to participate in maximal exercise 5. Type one or type two diabetes 6. Diagnosis of cancer or undergoing cancer treatment in the past 12 months 7. Taking blood-thinning medication or the presence of a bleeding disorder 8. Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines) |
Country | Name | City | State |
---|---|---|---|
Canada | Univeristy if British Columbia | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
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* Note: There are 31 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in repetitions completed for 30% pre-training 1- Repetition maximum (Single leg Knee extension) | The number of single leg knee extension repetitions that one can complete at 30% of their pre-training 1-RM | Change from baseline to 6 weeks | |
Primary | Change in Repetitions completed for 30% pre-training 1- Repetition maximum (Single leg Knee extension) | The number of single leg knee extension repetitions that one can complete at 30% of their pre-training 1-RM | Change from baseline to 12 weeks | |
Primary | Change in CFPE index (Capillary to fiber ratio normalized to fiber perimeter) | Mean number of capillaries touching each muscle fibre (normalized to the fibre perimeter). Assessed using imaging of muscle samples gathered via muscle biopsies. | Change from baseline to 12 weeks | |
Primary | Change in Maximal Citrate synthase (CS) Activity | Indicator of Mitochondrial content and function in skeletal muscle. | Change from baseline to 12 weeks | |
Secondary | Change in Single leg Knee extension 1- Repetition maximum (weight lifted) | Maximum Weight lifted for 1 repetition of single leg knee extension exercise. | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Knee extension 1- Repetition maximum (weight lifted) | Maximum Weight lifted for 1 repetition of single leg knee extension exercise. | Change from baseline to 12 weeks | |
Secondary | Change in Single leg Knee extension Isometric Maximum Voluntary Contraction | Maximal force production at 90 degrees of knee flexion. Assessed via Biodex | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Knee extension Isometric Maximum Voluntary Contraction | Maximal force production at 90 degrees of knee flexion. Assessed via Biodex | Change from baseline to 12 weeks | |
Secondary | Change in Single leg Knee Flexion Isometric Maximum Voluntary Contraction | Maximal force production at 90 degrees of knee flexion. Assessed via Biodex | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Knee Flexion Isometric Maximum Voluntary Contraction | Maximal force production at 90 degrees of knee flexion. Assessed via Biodex | Change from baseline to 12 weeks | |
Secondary | Change in Single leg Knee Flexion Isokentic Maximum Voluntary Contraction | Maximal force production at 60 degrees/second. Assessed via Biodex | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Knee Flexion Isokentic Maximum Voluntary Contraction | Maximal force production at 60 degrees/second. Assessed via Biodex | Change from baseline to 12 weeks | |
Secondary | Change in Single leg Knee Extension Isokentic Maximum Voluntary Contraction | Maximal force production at 60 degrees/second. Assessed via Biodex | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Knee Extension Isokentic Maximum Voluntary Contraction | Maximal force production at 60 degrees/second. Assessed via Biodex | Change from baseline to 12 weeks. | |
Secondary | Change in Single leg VO2 Peak on Kicking ergometer (ml/kg leg lean mass/min) | Maximal Oxygen consumption/minute of single leg. | Change from baseline to 12 weeks. | |
Secondary | Change in Single leg Wingate test on kicking ergometer (Max Power) | maximum 5 second power achieved during Single leg Wingate test on kicking. ergometer | Change from baseline to 6 weeks | |
Secondary | Change in Single leg Wingate test on kicking ergometer (Max Power) | maximum 5 second power achieved during Single leg Wingate test on kicking. ergometer | Change from baseline to 12 weeks | |
Secondary | Change in Leg lean mass | Assessed via Dual X-ray absorptiometry. Measured in Kg. | Change from baseline to 12 weeks. | |
Secondary | Change in Vastus Lateralis Cross sectional area (CSA) | CSA of vests laterals muscle assessed via ultrasonography. | Change from baseline to 12 weeks. | |
Secondary | Change in Type I and II Fiber Cross sectional area (CSA) | Mean CSA of Type I and II muscle fibers using imaging of muscle samples gathered via muscle biopsies. | Change from baseline to 12 weeks | |
Secondary | Change in Capillary to fiber ratio (C/FI) | Mean number of capillaries touching each muscle fibre. Assessed using imaging of muscle samples gathered via muscle biopsies. | Change from baseline to 12 weeks |
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