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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02014233
Other study ID # UTTW-N3-1
Secondary ID
Status Completed
Phase N/A
First received October 25, 2013
Last updated May 19, 2016
Start date June 2013
Est. completion date March 2014

Study information

Verified date May 2016
Source University of Toronto
Contact n/a
Is FDA regulated No
Health authority Canada: Ethics Review Committee
Study type Interventional

Clinical Trial Summary

Nerves are the rate limiting factor that control muscle function. However, it is unknown if a nutritional supplement can change the nerve-muscle interaction, and therefore alter human performance. This study will be the first to examine the effects of omega-3 supplementation on neuromuscular function in trained individuals.


Description:

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Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Omega-3

Olive oil


Locations

Country Name City State
Canada University of Toronto Toronto Ontario

Sponsors (1)

Lead Sponsor Collaborator
University of Toronto

Country where clinical trial is conducted

Canada, 

References & Publications (5)

Behm DG, St-Pierre DM, Perez D. Muscle inactivation: assessment of interpolated twitch technique. J Appl Physiol (1985). 1996 Nov;81(5):2267-73. — View Citation

MERTON PA. Voluntary strength and fatigue. J Physiol. 1954 Mar 29;123(3):553-64. — View Citation

Millet GY, Tomazin K, Verges S, Vincent C, Bonnefoy R, Boisson RC, Gergelé L, Féasson L, Martin V. Neuromuscular consequences of an extreme mountain ultra-marathon. PLoS One. 2011 Feb 22;6(2):e17059. doi: 10.1371/journal.pone.0017059. — View Citation

Presland JD, Dowson MN, Cairns SP. Changes of motor drive, cortical arousal and perceived exertion following prolonged cycling to exhaustion. Eur J Appl Physiol. 2005 Sep;95(1):42-51. Epub 2005 Jun 23. — View Citation

Rodacki CL, Rodacki AL, Pereira G, Naliwaiko K, Coelho I, Pequito D, Fernandes LC. Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr. 2012 Feb;95(2):428-36. doi: 10.3945/ajcn.111.021915. Epub 2012 Jan 4. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Change from baseline in maximum voluntary contraction force Participants will be seated with their right knee fixed at 90°. The right ankle will be restrained by a padded cuff attached in series to a load cell. Participants will be instructed to contract their quadriceps maximally by trying to extending their leg. The load cell will measure the maximum force produced. 21 days No
Secondary Change from baseline in vertical jump height Participants will perform both squat jumps and counter movement jumps on a force plate. Jump height (cm) will be measured. 21 days No
Secondary Change from baseline in number of push-ups Participants will perform the maximum number of push-ups possible in one minute while maintaining proper form. A one minute rest will be given and then they will repeat the same procedure. 21 days No
Secondary Change from baseline in number of 10RM squats Participants will complete as many reps of back squats possible using the 10 repetition maximum weight established during familiarization. 21 days No
Secondary Change from baseline in Wingate test peak power Participants will perform a 30 second maximal cycling sprint with the resistance set at 7.5% of their baseline body weight. Peak power, average power, fatigue index and cadence will all be measured. 21 days No
Secondary Change from baseline in 250 kJ cycling time trial time to completion Participants will complete 250 kJ (kilo Joules) of cycling on an ergometer which is equivalent to 10km. Time to completion and average power (Watts) will be measured. Baseline and 21 days No
Secondary Change from baseline in Pre/Post maximal voluntary contraction force Pre/Post quadriceps maximal voluntary contraction force is the difference in maximal voluntary contraction force measured at the beginning and end of each testing session to determine changes in neuromuscular function as a result of the other fatiguing tests. 21 days No
Secondary Change from baseline in quadriceps voluntary activation Participants femoral nerve will be electrically stimulated during the maximal voluntary contraction. Voluntary activation is the difference in muscle force output between the voluntary contraction and the electrically stimulated contraction. 21 days No
Secondary Change from baseline in Wingate test average power Participants will perform a 30 second maximal cycling sprint with the resistance set at 7.5% of their baseline body weight. Peak power, average power, fatigue index and cadence will all be measured. 21 days No
Secondary Change from baseline in Wingate test fatigue index Participants will perform a 30 second maximal cycling sprint with the resistance set at 7.5% of their baseline body weight. Peak power, average power, fatigue index and cadence will all be measured. 21 days No
Secondary Change from baseline in Wingate test cadence Participants will perform a 30 second maximal cycling sprint with the resistance set at 7.5% of their baseline body weight. Peak power, average power, fatigue index and cadence will all be measured. 21 days No
Secondary Change from baseline in 250 kJ cycling time trial average power Participants will complete 250 kJ of cycling on an ergometer which is equivalent to 10km. Time to completion and average power (Watts) will be measured. Baseline and 21 days No
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