Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise — EXETOR  

Muscle Strength Clinical Trial

Official title: Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise.

Status Terminated

Clinical Trial Summary

This is an exploratory study based on the hypothesis that kidney transplant patients treated with an immunosuppressive therapy based on an inhibitor of the mammalian target of rapamycin (m-TOR) may increase resistance to physical exercise, which would result in an improvement in the quality of life of these patients.

Clinical Trial Description

The hypothesis of the present study is that, with respect to calcineurin inhibitors, the mTOR inhibitor-based immunosuppression may alter the physical exercise capacity in renal transplant patients.

This is based on recent data obtained. Regarding metabolism there is evidence that inhibition of mTOR, reduces muscle glucose utilization, as well as, increase fatty acid oxidation. On the other hand, has shown that drugs based on mTOR inhibitors in the context of excess of nutrients improves intracellular glucose uptake in skeletal muscle cells. Through these mechanisms could increase resistance to physical exercise, which would result in an improvement in the quality of life of patients. Nevertheless, there isn't any paper that has explored this hypothesis accurately. ;

Study Design

Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Disorder Related to Renal Transplantation
• Exercise, Aerobic
• Muscle Strength

• NCT number: NCT01561404
• Study type: Interventional
• Source: Hospital Universitari de Bellvitge
• Status: Terminated
• Phase: Phase 4
• Start date: September 2011
• Completion date: December 2013