The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Muscle Strength Clinical Trial

Official title:

The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01346995
• Other study ID #: 072.07
• Status: Completed
• Phase: N/A
• First received: May 2, 2011
• Last updated: May 3, 2011
• Start date: February 2010
• Est. completion date: August 2010

Study information

• Verified date: February 2010
• Source: Frederiksberg University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: The Capital Region of Denmark
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: August 2010
• Est. primary completion date: August 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 35 Years

Eligibility

Inclusion Criteria:

• aged between 20 to 35 years

• healthy

• untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

• symptomatic musculoskeletal diseases

• history of traumatic injuries to muscles, tendons or joints of the lower extremity

• knee joint pain within a month prior to enrollment

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Muscle Strength

Intervention

Other:
• Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
• Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Frederiksberg University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Isokinetic knee muscle strength		At baseline and after 8 weeks of exercise	No
Secondary	One-leg chair rise		At baseline and after 8 weeks of exercise	No