Muscle Strain Clinical Trial
Official title:
Skeletal Muscle Strain Injuries and the Connective Tissue: Characterization, Recovery and Optimal Treatment
Firstly, the investigators aim to study the biochemical, structural and functional changes
associated with acute muscle strain injury in the acute phase and during rehabilitation in
vivo. Specific factors present after the injury and their effects on connective tissue cells
will be examined in vitro.
Secondly, the investigators will investigate individuals with chronic pain, scar tissue and
inferior function after a previous muscle strain injury and test a specific rehabilitation
program to alleviate pain and disabilities associated with the preceding muscle injury. The
investigators have the following hypotheses:
1. Humoral growth factors and pro-inflammatory macrophages released into the injured area
post strain injury stimulate formation of connective tissue in vitro.
2. Early onset of rehabilitation will be superior to a delayed start of rehabilitation for
the healing process, in regards to structural improvement of tissue and better clinical
function.
3. Scar tissue following a muscle strain injury is characterized by disorganized structure
of connective tissue.
4. Mechanical loading in the form of heavy eccentric muscle activity for 12 weeks will lead
to a local re-modeling of scar tissue, and result in improved function and reduced
symptoms in patients with chronic pain and impaired function after a previous muscle
injury.
n/a
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