Protein Ingestion and Muscle Carnitine Uptake

Muscle, Skeletal Clinical Trial

Official title:

The Effects of an Insulinotropic Protein-carbohydrate Beverage on L- Carnitine Absorption and Muscle Carnitine Uptake

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02535897
• Other study ID #: G26062012 BMS
• Status: Completed
• Phase: Phase 1
• First received: August 24, 2015
• Last updated: August 28, 2015
• Start date: July 2013
• Est. completion date: July 2014

Study information

• Verified date: August 2015
• Source: University of Nottingham
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine whether increasing plasma carnitine availability can impact upon insulin-stimulated muscle carnitine uptake.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 7
• Est. completion date: July 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy

• Body mass index of 18-25 kg/cm2

Exclusion Criteria:

• Unhealthy

• Smoker

• Taking any medication that interferes with skeletal muscle metabolism

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Muscle, Skeletal

Intervention

Dietary Supplement:
• Flavoured water

• Flavoured water + carbohydrate

• Flavoured water + carbohydrate + protein

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Nottingham

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle carnitine uptake	Change in forearm carnitine uptake (measured using arterialised-venous - venous balance technique) in response to intervention.	180 minutes	No