The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

Muscle Metabolism Clinical Trial

Official title:

The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06129513
• Other study ID #: 22-02-02-B-02
• Status: Completed
• Phase: N/A
• Start date: February 24, 2022
• Est. completion date: October 31, 2022

Study information

• Verified date: November 2023
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: October 31, 2022
• Est. primary completion date: October 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• BMI between 18 - 30

• Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)

Exclusion Criteria:

• Any metabolic impairment

• Any cardiovascular impairment

• Smoking

• Lactose intolerance

• Allergies to products containing dairy, meat or nuts

• Prescribed intake of over the counter pharmaceuticals

Related Conditions & MeSH terms

• Muscle Metabolism

Intervention

Behavioral:
• Bilateral resistance exercise
A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Dietary Supplement:
• Whey protein
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate
• Plant-blend protein
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Locations

Country	Name	City	State
United Kingdom	University of Exeter	Exeter

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-exercise myofibrillar protein synthesis following protein ingestion	The fractional synthetic rate of myofibrillar proteins	4 hours
Secondary	Post-exercise myofibrillar protein synthesis during the early postprandial period	The fractional synthetic rate of myofibrillar proteins	2 hours
Secondary	Post-exercise myofibrillar protein synthesis during the late postprandial period	The fractional synthetic rate of myofibrillar proteins	2 hours
Secondary	Plasma amino acid response	Post-exercise and postprandial change in plasma amino acid concentrations and availability	4 hours
Secondary	Serum insulin response	Post-exercise and postprandial change in serum insulin concentrations	4 hours