Muscle Loss Clinical Trial
— ROLOfficial title:
Carnitine Supplementation and Skeletal Muscle Function in Aging
Verified date | August 2021 |
Source | Gdansk University of Physical Education and Sport |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content. A secondary aim of this project is to investigate the effect of carnitine with leucine supplementation on muscle strength and body composition.
Status | Completed |
Enrollment | 16 |
Est. completion date | January 31, 2018 |
Est. primary completion date | May 15, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 29 Years |
Eligibility | Inclusion Criteria: - must be able to swallow tablets Exclusion Criteria: - cardiovascular disease - liver disease - kidney disease - neuromuscular disease - gastrointestinal disorders (including stomach ulcers and erosions) - diabetes - other severe chronic diseases |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Gdansk University of Physical Education and Sport | Medical University of Gdansk |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle Carnitine Concentration using UPLC-MS/MS | vastus lateralis muscle biopsy taken before and after the supplementation procedure (~20 cm proximal to the knee joint using a thin biopsy needle); carnitine concentration determined using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method | 24 weeks | |
Secondary | Muscle Strength using Biodex System 4 Pro dynamometer | Peak torque measured by performing maximum voluntary contractions during isometric knee extension and flexion. The test performed in concentric-concentric mode consisting maximum 4-s knee extensor isometric contraction and maximum 4-s knee flexor isometric contraction, separated by 20-s recovery, repeated three times. Muscle isokinetic strength assessed in 5 repetitions of flexion and extension at a speed of 60°/s. Muscle endurance assessed in 10 repetitions at 300°/s determine the ability of the muscle to maintain the work. Strength testing performed on the Biodex System 4 Pro dynamometer. | 24 weeks | |
Secondary | Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720). | The InBody720 measures impedance of five segments of the body (each arm, each leg, trunk) at frequencies of 1, 5, 50, 250, 500, and 1000 kHz through the 8-polar tactile-electrode. Based on the impedance, body fat mass, fat free mass, and skeletal muscle mass are calculated. | 24 weeks |
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