Muscle Loss Clinical Trial
Official title:
Anabolic Potential of Adding 3-hydroxybutyrate (3-OHB) to Whey Protein in a Catabolic Inflammatory Disease Model: A Human Randomized Controlled Trial
This study aims to investigate the muscle anabolic potential of adding ketone (3-hydroxybutyrate) to whey protein compared with isocaloric, isonitrogenous whey protein in a human model of inflammatory catabolic disease. Further, this study aims to investigate whether the same amount of whey protein has different effects on muscles in an catabolic inflammatory setting compared with a healthy setting.
Background: Muscle wasting during hospitalization is caused by a combination of
immobilization (bed rest), hypocaloric diet and inflammation (e.g. sepsis), and preventive
measures are needed. Whey protein is particularly potent in inducing muscle protein synthesis
compared with other proteins, at least in healthy populations. Further, the ketone body
3-hydroxybutyrate (3-OHB) effectively preserved muscle in a model of acute inflammatory
disease. However, little is known about whether 3-OHB can potentiate the effects of whey
protein in a catabolic inflammatory setting.
Aim: This study aims to investigate the muscle anabolic potential of adding ketone (3-OHB) to
whey protein compared with isocaloric, isonitrogenous whey protein in a human model of
catabolic inflammatory disease. Further, this study aims to investigate whether the same
amount of whey protein has different effects on muscles in an catabolic inflammatory setting
compared with a healthy setting.
Hypothesis:
1. 3-OHB potentiates the effect of whey protein in maintaining muscle mass in a catabolic
inflammatory setting.
2. The same amount of whey protein will have decreased muscle anabolic effects during
catabolic inflammatory conditions compared with healthy conditions
Interventions:
In a randomized crossover design, eight healthy, lean, young men will undergo either:
i) Healthy conditions (overnight fast) + whey protein^ ii) Catabolic conditions
(Inflammation (LPS) + 36-hour fast and bed rest*) + whey protein^ iii) Catabolic
conditions (Inflammation (LPS) + 36-hour fast and bed rest*) + 3-OHB/whey protein^"
*LPS will be administered (1 ng/kg) the day prior to the study together with fast and
bed rest. On the study day LPS (0.5 ng/kg) will be injected.
^Beverages will be isonitrogenous and isocaloric (fat will be added) with 45 g whey
protein + 20 g maltodextrin. Bolus/sip administration will be applied (1/3 bolus, 1/2
sip)
" 50 grams of 3-OHB will be orally administered (1/2 bolus, 1/2 sip)
Before each study day:
The participants arrive fasting (only tap water allowed) by taxi on the study days. They
have been without febrile disease the week prior to investigation, and have not
performed exercise for 24 hours.
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