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Essential Amino Acids Supplementation and Muscle Protein Synthesis

Muscle Loss Clinical Trial

Official title:
The Effect of Amino Acid Supplementation on Skeletal Muscle Protein Turnover Following Endurance Exercise

Clinical Trial Summary

The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01366924
Study type Interventional
Source United States Army Research Institute of Environmental Medicine
Contact
Status Completed
Phase Phase 1/Phase 2
Start date May 2007
Completion date July 2010
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