Muscle Disuse Clinical Trial
Official title:
Muscle Immune Cells During Disuse and Recovery in Aging and Metabolic Disease
This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week limb immobilization period.
Visit 1 (Pre-testing)- After signing a consent form, participants will undergo a blood screening and an oral glucose tolerance test. After the visit, participants will be provided with a step activity monitor to track their level of activity. A dietary assessment will also be determined. Visit 2- At a later time, the participant will return to the research center for a biopsy, blood draw, body composition scan, MRI and muscle strength testing. 2-week leg immobilization period- After visit 2 , the participant will return home and undergo a 14-day leg immobilization period using the equipment and instructions provided at visit 2. Visit 3- During the limb immobilization period, participant will return to the research center for a single blood draw. Visit 4- At the end of the 2-week limb immobilization period, the participant will return to the research center to undergo another biopsy, blood draw, body composition scan, MRI and muscle strength testing. Visit 5- 2 days after the 2-week limb immobilization period, the participant will return for a biopsy and blood draw. Visit 6- 7 days after the 2-week limb immobilization period, the participant will be asked to return for a final biopsy, blood draw, body composition scan, MRI and muscle strength testing. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01521637 -
The Efficacy of Neuromuscular Electrical Stimulation to Attenuate Muscle Loss
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N/A |