Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Maximal Voluntary Contraction at baseline |
One-repetition maximum (1RM) test: leg extension and leg curl machines |
Baseline |
|
Primary |
Change from baseline Maximal Voluntary Contraction at 72-hours post-exercise |
One-repetition maximum (1RM) test: leg extension and leg curl machines |
72-hours after the exercise bout |
|
Primary |
Change from baseline Maximal Voluntary Contraction at 168-hours post-exercise |
One-repetition maximum (1RM) test: leg extension and leg curl machines |
168-hours after the exercise bout |
|
Primary |
Creatine kinase concentration at baseline |
Serum concentration of creatine kinase from venous blood sampling |
Immediately pre-exercise |
|
Primary |
Change from baseline in Creatine Kinase concentration immediately post-exercise |
Serum concentration of creatine kinase from venous blood sampling |
Immediately after the exercise bout |
|
Primary |
Change from baseline in Creatine Kinase concentration at 24-hours post-exercise |
Serum concentration of creatine kinase from venous blood sampling |
24-hours after the exercise bout |
|
Primary |
Change from baseline in Creatine Kinase concentration at 48-hours post-exercise |
Serum concentration of creatine kinase from venous blood sampling |
48-hours after the exercise bout |
|
Primary |
Change from baseline in Creatine Kinase concentration at 72-hours post-exercise |
Serum concentration of creatine kinase from venous blood sampling |
72-hours after the exercise bout |
|
Primary |
Change from baseline in Creatine Kinase concentration at 168-hours post-exercise |
Serum concentration of creatine kinase from venous blood sampling |
168-hours after the exercise bout |
|
Primary |
Interleukin-6 concentration at baseline |
Serum concentration of Interleukin-6 from venous blood sampling |
Immediately pre-exercise |
|
Primary |
Change from baseline in Interleukin-6 concentration immediately post-exercise |
Serum concentration of Interleukin-6 from venous blood sampling |
Immediately after the exercise bout |
|
Primary |
Change from baseline in Interleukin-6 concentration at 24-hours post-exercise |
Serum concentration of Interleukin-6 from venous blood sampling |
24-hours after the exercise bout |
|
Primary |
Change from baseline in Interleukin-6 concentration at 48-hours post-exercise |
Serum concentration of Interleukin-6 from venous blood sampling |
48-hours after the exercise bout |
|
Primary |
Change from baseline in Interleukin-6 concentration at 72-hours post-exercise |
Serum concentration of Interleukin-6 from venous blood sampling |
72-hours after the exercise bout |
|
Primary |
Change from baseline in Interleukin-6 concentration at 168-hours post-exercise |
Serum concentration of Interleukin-6 from venous blood sampling |
168-hours after the exercise bout |
|
Primary |
Muscle soreness (pressure algometry) at baseline |
Self-perceived rating of muscle soreness with use of pressure algometry |
Immediately pre-exercise |
|
Primary |
Change in muscle soreness (pressure algometry) immediately post-exercise |
Self-perceived rating of muscle soreness with use of pressure algometry |
Immediately after the exercise bout |
|
Primary |
Change in muscle soreness (pressure algometry) at 24-hours post-exercise |
Self-perceived rating of muscle soreness with use of pressure algometry |
24-hours after the exercise bout |
|
Primary |
Change in muscle soreness (pressure algometry) at 48-hours post-exercise |
Self-perceived rating of muscle soreness with use of pressure algometry |
48-hours after the exercise bout |
|
Primary |
Change in muscle soreness (pressure algometry) at 72-hours post-exercise |
Self-perceived rating of muscle soreness with use of pressure algometry |
72-hours after the exercise bout |
|
Primary |
Change in muscle soreness (pressure algometry) at 168-hours post-exercise |
Self-perceived rating of muscle soreness with use of pressure algometry |
168-hours after the exercise bout |
|
Primary |
Muscle soreness (visual analogue scale, VAS) at baseline |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
Immediately pre-exercise |
|
Primary |
Change in muscle soreness (visual analogue scale, VAS) immediately post-exercise |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
Immediately after the exercise bout |
|
Primary |
Change in muscle soreness (visual analogue scale, VAS) at 24-hours post-exercise |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
24-hours after the exercise bout |
|
Primary |
Change in muscle soreness (visual analogue scale, VAS) at 48-hours post-exercise |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
48-hours after the exercise bout |
|
Primary |
Change in muscle soreness (visual analogue scale, VAS) at 72-hours post-exercise |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
72-hours after the exercise bout |
|
Primary |
Change in muscle soreness (visual analogue scale, VAS) at 168-hours post-exercise |
Self-perceived rating of muscle soreness while performing a bodyweight squat with use of a visual analogue scale (0 - not sore at all, 10 - extremely sore) |
168-hours after the exercise bout |
|
Primary |
Range of motion at baseline |
Flexibility of the exercised limb as determined by goniometry |
Immediately pre-exercise |
|
Primary |
Change in range of motion immediately post-exercise |
Flexibility of the exercised limb as determined by goniometry |
Immediately after the exercise bout |
|
Primary |
Change in range of motion at 24-hours post-exercise |
Flexibility of the exercised limb as determined by goniometry |
24-hours after the exercise bout |
|
Primary |
Change in range of motion at 48-hours post-exercise |
Flexibility of the exercised limb as determined by goniometry |
48-hours after the exercise bout |
|
Primary |
Change in range of motion at 72-hours post-exercise |
Flexibility of the exercised limb as determined by goniometry |
72-hours after the exercise bout |
|
Primary |
Change in range of motion at 168-hours post-exercise |
Flexibility of the exercised limb as determined by goniometry |
168-hours after the exercise bout |
|
Primary |
Limb circumference at baseline |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
Immediately pre-exercise |
|
Primary |
Change in limb circumference immediately post-exercise |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
Immediately after the exercise bout |
|
Primary |
Change in limb circumference at 24-hours post-exercise |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
24-hours after the exercise bout |
|
Primary |
Change in limb circumference at 48-hours post-exercise |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
48-hours after the exercise bout |
|
Primary |
Change in limb circumference at 72-hours post-exercise |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
72-hours after the exercise bout |
|
Primary |
Change in limb circumference at 168-hours post-exercise |
Measure of leg circumference with use of standard anthropometric tape to indicate muscle swelling |
168-hours after the exercise bout |
|