Muscle Damage Clinical Trial
— WheyProteinOfficial title:
The Effects of Pasture-raised Versus Conventional Whey Protein Supplementation on Vascular Function and Markers of Exercise-induced Muscle Damage and Inflammation in Resistance-trained Individuals
NCT number | NCT05100459 |
Other study ID # | 12559 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | November 15, 2021 |
Est. completion date | June 14, 2022 |
Verified date | February 2023 |
Source | Indiana University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Intense exercise can bring about various side effects to one's body. Less range of motion, increased pain sensitivity, increased muscle swelling, and decreased muscle strength can occur immediately after exercise. These side effects can be referred to exercise induced muscle damage (EIMD) and can sometimes last many days. This study's goal is to evaluate the effects of various protein supplements on EIMD symptoms as well as on blood vessel health during the recovery period after muscle damaging exercise.
Status | Completed |
Enrollment | 39 |
Est. completion date | June 14, 2022 |
Est. primary completion date | June 14, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Men and women 18-40 years old - =3 months uninterrupted training of =3 days/week of resistance training - Self-reported to be healthy Exclusion Criteria: - Not within defined age range - History of allergy to dairy products - History of experiencing pain while exercising in the lower extremities (i.e., hips/knees) - Current use of anti-inflammatory/anti-pain medication (i.e., nonsteroidal anti-inflammatory drugs (NSAIDs) such as Tylenol, Advil, or Aleve - Are pregnant or could possibly be pregnant by self-report - People who answer 'yes' to any of the pre-participation screening questions on the PAR-Q questionnaire. |
Country | Name | City | State |
---|---|---|---|
United States | Indiana University School of Public Health | Bloomington | Indiana |
Lead Sponsor | Collaborator |
---|---|
Indiana University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Titin | Muscle damage assessment via urinary titin via ELISA (MBS2881644, Human Titin ELISA® Kit, MyBioSource.com, Inc., San Diego, USA). Units: pmol | Four days | |
Primary | Isometric torque | Isometric torque assessment of right leg extensors will be conducted at a knee angle of 90 degrees using a calibrated load cell (model Z Tension Load Cell; Dillon, Fairmont, MN) Units: Nm | Four days | |
Primary | Range of motion | Hamstring flexibility and stiffness will be measured using a sit-and-reach box (Lafayette Instrument Company, Lafayette, IN) test. Units: cm | Four days | |
Primary | delayed onset muscle soreness | Visual analog scale of muscle soreness (delayed onset muscle soreness; DOMS) - Knee extensor soreness will be assessed using a visual analogue scale with "no soreness" indicated at one end (score 0) and "unbearably painful" at the other (score 100). Units: arbitrary units | Four days | |
Primary | Pain pressure threshold | Muscle tenderness, known as pain pressure threshold, will be quantified using a digital algometer (Force One, Wagner Instruments, Greenwich, CT) on pre-marked sites at two specific points on the quadriceps (rectus femoris-RF and vastus lateralis-VL) and one on the calf (gastrocnemius-GM). Units: percentage change from baseline | Four days | |
Primary | Peripheral Fatigue | Peripheral fatigue will be assessed via magnetic stimulation (Magstim 200-2; Jali Medical, Newton, MA, USA) of the femoral nerve, which will be used to elicit a quadriceps twitch. Units: Nm | Four days | |
Primary | Countermovement Jump | A linear position transducer (GymAware Powertool; Kinetic Performance Technology, Canberra, Australia) interfaced with an iPad (Apple, CA, USA) will be used to calculate countermovement jump (CMJ) height. Units: cm | Four days | |
Primary | Barbell back squat velocity | The mean velocity of the barbell will be measured using the linear position transducer as per the load velocity profile relationship. Units: m/s | Four days | |
Secondary | Arterial Stiffness | Utilizing carotid femoral pulse wave velocity via applanation tonometry, considered the non-invasive gold standard of central arterial stiffness, the ATCOR SphygmoCor® (Naperville, IL, USA) device will be utilized. Units: m/sec | Four days |
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