The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Recovery Following Strenuous Exercise

Muscle Damage Clinical Trial

— CurraNZ_MD  

Official title:

The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Indices of Muscle Damage Following Strenuous Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05010057
• Other study ID #: UEC/2015/112/FHMS
• Status: Completed
• Phase: N/A
• Start date: June 10, 2016
• Est. completion date: September 1, 2018

Study information

• Verified date: August 2021
• Source: University of Surrey
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise. The investigation will compare responses between an experimental (NZBC capsule, 300 mg/day) and placebo (PLA capsule, 300 mg sugar) group. Participants will attend a screening session where they will consent to the study, complete a pre-activity medical questionnaire and have their height, weight and resting blood pressure measured. If the participants meet the inclusion criteria they will perform a familarisation session on the muscle strength assessment. Participants will be randomized to NZBC or placebo groups, and consume one capsule in the morning (between 6-10 am) for 12 days. This is a double-blinded study, which means that the participant and the study team will not know which group the participants are assigned to until the study is over. On day 8 participants will perform a strenuous bout of upper body resistance exercise on the isokinetic dynamometer (exercise device). Muscle strength and soreness, arm circumference, and elbow range of motion will be measured, and a fasted blood sample will be collected, before and 24, 48, 72 & 96 hours after the muscle fatigue protocol (on days 9, 10, 11 & 12). A marker of muscle damage (creatine kinase [CK] concentration) will be measured in the blood samples. Participants will also be asked to complete a 6-day dietary record, beginning on day 7 and ending on the final day of testing (day 12).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: September 1, 2018
• Est. primary completion date: September 1, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Males and Females

• 18 - 45 years old

• BMI: 19 - 29.9 kg/m2

• Healthy: no active disease process that could interfere with endpoints measured as determined by medical history

Exclusion Criteria:

• Smoking and tobacco use

• Takes medication [excluding contraception]

• BMI = 30 kg/m2

• Hypertensive (diastolic > 90 and/or systolic blood pressure > 140 mmHg)

• History of musculoskeletal upper limb injuries

• Performs regular resistance exercise (> 2 sessions per week)

• Uses dietary supplements that could influence muscle recovery or function (e.g. protein supplements, antioxidants etc)

Related Conditions & MeSH terms

• Muscle Damage

Intervention

Dietary Supplement:
• New Zealand blackcurrants (NZBC)
NZBC capsules containing anthocyanin-rich blackcurrant extract
• Placebo (PLA)
Placebo capsules containing microcrystalline cellulose

Locations

Country	Name	City	State
United Kingdom	Surrey Human Performance Institute	Guildford	Surrey

Sponsors (1)

Lead Sponsor	Collaborator
University of Surrey

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline in creatine kinase (CK) concentration at 72 hours post-exercise	Serum biomarker for muscle damage	At baseline (pre-exercise) and 72 hours post-exercise.
Primary	Change from baseline in creatine kinase (CK) concentration at 96 hours post-exercise	Serum biomarker for muscle damage	At baseline (pre-exercise) and 96 hours post-exercise..
Secondary	Change in maximum voluntary contraction (MVC) from baseline to 96 hours post-exercise	Muscle function measure; maximal voluntary isometric contraction (torque, Nm) performed on isokinetic dynamometer	At baseline (pre-exercise) and post-exercise time points (at 0, 24, 48, 72 and 96 hours respectively).
Secondary	Change in rating of Delayed Onset of Muscle Soreness (DOMS) from baseline to 96 hours post-exercise	Self-reported perception of muscle soreness using a visual analogue scale (VAS), from 'no soreness' [0 mm] on the left anchor point to 'extremely sore' [100 mm] on the right	At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Secondary	Change in joint range of motion (ROM) from baseline to 96 hours post-exercise	Elbow ROM measured using a goniometer	At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).
Secondary	Change in mid arm circumference (MAC) from baseline to 96 hours post-exercise	Mid-upper arm circumference measured at the midpoint of the distance from the acromion process (acromiale) to the olecranon process (radiale).	At baseline (pre-exercise) and post-exercise time points (at 24, 48, 72 and 96 hours respectively).