Muscle Damage Clinical Trial
Official title:
The Effect of β-hydroxy-β-methylbutyrate Supplementation on Muscle Damage Induced by Resistance Exercise
The study aims at assessing the influence of β-hydroxy-β-methylbutyrate (HMB) supplementation (4.0 g/day) supplemented for 7 days in a group of speed-strength trained individuals on lower-body strength performance, selected muscle histological, molecular and blood markers of muscle recovery in response to resistance exercise-induced muscle damage.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | January 1, 2025 |
Est. primary completion date | December 1, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - written informed consent from all participants before the study - a current medical clearance to practice sports, - training experience: at least 1 year strength training programs that include lower limbs, - minimum of 3 workout sessions (strength/resistance training) a week, - protein intake in customary diet and during the study protocol > 1.6g / kg of body mass per day, - individual maximum strength greater than 2.5 times the body weight for the 1RM test in the leg-press. Exclusion Criteria: - current injury, - any health-related contraindication, - declared general feeling of being unwell, - unwilling to follow the study protocol, - serious disease or metabolic problems, - intake of creatine, caffeine or beta-alanine, or other ergogenic supplements 3 months before the beginning of the study, - history of anabolic androgenic steroids or drugs use that may interfere with muscle mass control (eg, corticosteroids), or affect physical performance, - smoking and tobacco use, - presence of infectious disease in the previous 4 weeks of the study. |
Country | Name | City | State |
---|---|---|---|
Brazil | Escola de Educação Física e Esporte da USP / School of Physical Education and Sport - USP. | São Paulo | São Paulo - SP |
Lead Sponsor | Collaborator |
---|---|
Poznan University of Physical Education | Escola de Educação Física e Esporte da Universidade de São Paulo (Brazil) - Parallel sponsor of the research, National Science Centre, Poland |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in the maximum voluntary isometric contraction (MVIC) after supplementation and exercises-induced muscle damage | Maximum voluntary isometric contraction (MVIC) torque (Nm) | Baseline, 24 hours and 48 hours after the end of exercises-induced muscle damage | |
Secondary | Change in the histological sarcomere integrity (after biopsy of the vastus lateralis muscle samples) after supplementation and exercises-induced muscle damage | The disruption of the Z-line areas and the total visible fiber area in muscle fibers (%) | Baseline, 24 hours and 48 hours after the end of exercises-induced muscle damage | |
Secondary | Change in the molecular potential (after biopsy of the vastus lateralis muscle samples) after supplementation and exercises-induced muscle damage | AKTser473, mTORSer2448, p70S7K1Thr389, 4E-BP1Ser65/Thr70, and 4EBP1Thr37/46 kinase activity (optical density) | Baseline, 24 hours and 48 hours after the end of exercises-induced muscle damage | |
Secondary | Change in the muscle cholesterol and mevalonate content (in the vastus lateralis muscle samples) after supplementation and exercises-induced muscle damage | Muscle cholesterol and mevalonate content (units) | Baseline, 24 hours and 48 hours after the end of exercises-induced muscle damage | |
Secondary | Changes in creatine kinase (CK) and lactate dehydrogenase (LDH) activity (IU) in blood after supplementation and exercises-induced muscle damage | CK and LDH activity (IU) | Baseline, 24 hours and 48 hours after the end of exercises-induced muscle damage | |
Secondary | Change in the strength performance results (at 80% of the individual's 1RM) in three resistance exercises (squats, the leg press, and leg extension) before and after supplementation and exercises-induced muscle damage | Number of repetitions in each sets of squats, the leg press, and leg extension (reps) | Baseline and 48 hours after the end of exercises-induced muscle damage |
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