Muscle Damage Clinical Trial
Official title:
Effect of Branched-chain Amino Acid Supplementation on Muscle Damage in Recreational Athletes
Seventy-eight recreational athletes who never resistance trained will be randomly assigned into three groups of twenty-six. Branched-chain amino acid will be supplemented for 18days at 0, 200 or 400 mg/body weight(kg)/day in jelly. Participants will be asked to perform elbow flexions on the 12th day of supplementation. Maximum voluntary contractions will be measured before, during and after the supplementation period to compare the effects of different doses of branched-chain amino acid has on muscle damage markers.
Previous studies have not been able to show consistent effects due to various reasons. The
major limitations are the lack of enough data on the amount and duration of branched-chain
amino acid supplementation, and the level of muscle damage for branched-chain amino acid to
be effective. Based on a recent meta-analysis, it has been suggested that to be effective,
branched-chain amino acid should be supplemented more than 200mg/kg/day before a
low-to-moderate intensity exercise bout. Therefore, this study is designed based on the above
suggestions and to compare the effect of different doses of branched-chain amino acid on
muscle damage markers in healthy recreational active individuals.
Three treatment groups (n=26) will be randomly assigned to be supplemented with either 200mg
BCAA/kg/day (BCAA200), 400mg BCAA/kg/day (BCAA400) or placebo (fiber supplement; PL).
Supplements will be provided in jelly in a single blind fashion to be ingested 1hour after
each of the three main daily meals for 18days. Anthropometric measurements (body weight, lean
mass, height), body temperature, ultrasound (US), strength assessment (maximal voluntary
contraction, MVC), resting metabolic rate (RMR), rate of perceived exertion (RPE), delayed
onset of muscle soreness (DOMS) and blood samples (duplicates; myoglobin; BCAA) will be
collected before, during and after the supplementation period at different time points (see
appendix for the above tables). Repeated-bout effect (RBE) on both arms will be measured 7
days after the damage inducing session.
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