The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

Muscle Damage Clinical Trial

Official title:

The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02839525
• Other study ID #: 51384015.5.0000.5345
• Status: Completed
• Phase: N/A
• First received: July 13, 2016
• Last updated: March 8, 2017
• Start date: July 26, 2016
• Est. completion date: February 9, 2017

Study information

• Verified date: March 2017
• Source: Federal University of Health Science of Porto Alegre
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study is a randomized, double-blinded, placebo-controlled trial that will include the participation of 69 women, aged 18-40 years. The aim of the study is to test nutritional strategies that help to minimize the effects of muscle damage induced by exercise.

The procedures will be performed at the Federal University of Health of Porto Alegre (UFCSPA).

Description:

The exercise-induced muscle damage is associated with eccentric activities affecting muscle structural unit through micro-injury that can promote a local inflammatory response, muscle damage and delayed onset muscle soreness. These events can cause an impact on athletic performance and lower adherence to the training programs. To optimize muscle recovery after the damage caused by exercise is essential to ensure adequate caloric intake , with required amounts of macronutrients and micronutrients. Recent studies have been showed that the protein intake before sleeping is a effective strategy to inhibit muscle protein degradation, stimulate muscle protein synthesis and facilitate adaptive response of skeletal muscle to physical exercise. Furthermore, evidences on the use of anti-inflammatory nutrients have suggested that diets rich in omega 3 can reduce inflammation through inhibition of pro-inflammatory mediators. Therefore, the intake of this nutrient combined with a protein meal before sleeps and the control of food intake can improve adherence to sports training. The study will consist of three groups where everyone will receive an individualized diet. A randomization procedure will determine the type of intervention. The distribution of the groups will be as follows: group 1 (control) - volunteers follow individualized diet and olive oil capsules and maltodextrin; group 2 - intervention with omega 3 more individualized diet ; group 3 - omega 3 and whey protein isolate intervention more individualized diet.

The order of procedures to be performed will be: (1) Nutritional and Anthropometric assessment; (2) Individual orientation of diet and distribution of supplements; (3) Baseline assessment (peak torque, muscle pain levels and vastus lateralis and rectus femoris echo intensity; (4) Muscle damage induction by eccentric exercise protocol; (5) Reviews after 24h, 48h, 72h, which will follow the routine and the methods applied at baseline.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2
• Est. completion date: February 9, 2017
• Est. primary completion date: January 9, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• 18 - 40 years aged

• BMI 18,5-25kg/m2

• physical exercise: < 150 minutes per week

Exclusion Criteria:

• pregnancy/ lactation

• vegetarian/vegan

• chronic disease

• pulmonary and neurologic disease

• muscle injury/knee muscle injury

• medication use: anti-inflammatory and anticoagulant

• fish oil and derivate allergy

• dietary supplements use in the last month: whey protein, casein, albumin, glutamin, meat and soy protein, creatine, branched chain amino acid, high calorie supplement, n-3 supplement and antioxidants

Related Conditions & MeSH terms

• Muscle Damage

Intervention

Dietary Supplement:
• Omega 3
3000mg of n-3 oil (2000mg EPA e 1000mg DHA)
• Isolate whey protein
23g of protein of whey protein
• Omega 3 and Isolate whey protein
3000mg of n-3 oil (2000mg EPA e 1000mg DHA) and 23g of protein of whey protein

Other:
• Eccentric exercise
100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Locations

Country	Name	City	State
Brazil	UFCSPA	Porto Alegre	Rio Grande do Sul

Sponsors (1)

Lead Sponsor	Collaborator
Federal University of Health Science of Porto Alegre

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quadriceps muscle strength evaluation (Peak Torque)	Three maximal isometric contractions of knee extensors will be performed by the isokinetic dynamometer equipment Biodex System 4 Pro (Biodex Medical Systems, USA).	One Year
Secondary	Evaluation of quadriceps muscle pain (Muscle pain levels)	The assessment of pain as muscle damage marker is expressed by a visual analog scale.	One year
Secondary	Vastus lateralis and rectus femoris echo intensity	Ultrasound images	One year