Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis

Status Completed

Clinical Trial Summary

The investigator's aim is to compare the efficacy of Ropinirole (Requip) to vitamin E in the treatment of muscle cramps in cirrhotic patients.

Clinical Trial Description

Muscle cramps are common in liver disease, especially in patients with cirrhosis. Despite the association of muscle cramps with liver disease, there is a paucity of information regarding treatment in these patients. Many treatment options have been reported in the literature but no standard of treatment has been established. Oral vitamin E replacement has been used successfully in the management of nocturnal muscle cramps in cirrhotic patients. Ropinirole is primarily used for treatment of restless leg syndrome. An off label trial of low dose Ropinirole in clinical practice has shown some success in providing relief of muscle cramps in patients with cirrhosis. This study will compare Ropinirole to vitamin E treatment in a prospective cross-over study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03176966
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase	Phase 4
Start date	September 2, 2016
Completion date	October 22, 2021

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