Quality of Life of Caregivers & Patients Suffering From Multiple System

Status Recruiting

Clinical Trial Summary

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that cause as other neurodegenerative diseases profound declines in functioning and thus, require caregiving for assistance with daily living. The aim of the study is to evaluate the effect of a multimodal intervention as proposed by the NYU Caregiver Counseling and Support Intervention (NYUCI) on the quality of life of patients and their caregivers.

Clinical Trial Description

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder, which is characterized by a variable combination of parkinsonism, cerebellar dysfunction, autonomic failure, and additional signs. No effective treatment is available. MSA patients have a poor prognosis with a median survival ranging between 6 and 10 years. MSA as other neurodegenerative diseases cause profound declines in functioning ; thus, many patients require caregivers for assistance with daily living. Caregiving can also be extremely stressful, and many caregivers experience declines in mental health. All of these repercussions contribute to the deterioration of the caregiver's quality of life and they can have an impact on the patient, in particular, on the patient's survival. Improving quality of life is a major element and identifying effective targeted interventions would bring immediate and direct benefit to patients and their families. In this context, it seems that a multimodal intervention as proposed by the NYU Caregiver Counseling and Support Intervention (NYUCI) developed by Mittelman could contribute to improve disease management and better coping with daily living difficulties. The NYUCI strategy combines sessions of individual and family counseling, support group participation, and additional on-call telephone consultations in a flexible counseling approach that is tailored to each caregiving family ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04965922
Study type	Interventional
Source	University Hospital, Bordeaux
Contact	Alexandra FOUBERT-SAMIER
Phone	05 57 82 14 20
Email	alexandra.samier-foubert@u-bordeaux.fr
Status	Recruiting
Phase	N/A
Start date	July 1, 2021
Completion date	July 1, 2023

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See also
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Completed	`NCT01155492` - Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease	N/A
Recruiting	`NCT04431713` - Exenatide Once-weekly as a Treatment for Multiple System Atrophy	Phase 2
Completed	`NCT04184063` - Study of NBMI Treatment in Patients With Atypical Parkinsons (PSP or MSA)	Phase 2
Recruiting	`NCT05121012` - Synaptic Loss in Multiple System Atrophy
Terminated	`NCT03589976` - A Futility Trial of Sirolimus in Multiple System Atrophy	Phase 2
Recruiting	`NCT04706234` - Systematic Assessment of Laryngopharyngeal Function in Patients With MSA, PD, and 4repeat Tauopathies
Completed	`NCT00368199` - Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes	N/A
Recruiting	`NCT04472130` - Neurodegenerative Diseases Registry
Recruiting	`NCT04876326` - Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy	N/A
Recruiting	`NCT04680065` - GDNF Gene Therapy for Multiple System Atrophy	Phase 1
Completed	`NCT03753763` - Safinamide for Multiple System Atrophy (MSA)	Phase 2
Recruiting	`NCT04250493` - Insulin Resistance in Multiple System Atrophy	N/A
Recruiting	`NCT06072105` - Medical Decision Making in Multiple System Atrophy	N/A
Terminated	`NCT02149901` - Water and Sudafed in Autonomic Failure	Early Phase 1
Terminated	`NCT00997672` - Lithium in Multiple System Atrophy	Phase 2

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Quality of Life of Caregivers and Patients Suffering From Multiple System Atrophy — QUA2-AMS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms