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Multiple Sclerosis (MS) clinical trials

View clinical trials related to Multiple Sclerosis (MS).

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NCT ID: NCT03456206 Active, not recruiting - Clinical trials for Inflammatory Bowel Diseases

Chronic Inflammatory Disease, Lifestyle and Risk of Disease

PROCID-DCH
Start date: November 10, 2018
Phase:
Study type: Observational [Patient Registry]

Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin diseases (psoriasis) and multiple sclerosis are diseases of the immune system that have some shared genetic and environmental predisposing factors, but still little is known on the effects of lifestyle as a prognostic factor on disease risk. This observational study will contribute to preexisting research on lifestyle factors by identifying diet factors associated with risk of developing CID, using prospective register data. The study will use data from all of the 57,053 participants in the Danish cohort "Diet, Health and Cancer (DHC)" together with registry data. Blood samples, anthropometric measures and questionnaire data on diet and lifestyle were collected at the DHC study entry. The National Patient Registry (NPR) will be used to obtain to identify patients with CID during follow-up. Follow-up information on death and immigration will be collected in March 2018 from the Danish Civil Registration Register. The outcome CID is defined as at least one of the following CIDs: Crohn's disease, ulcerative colitis, psoriasis/psoriatic arthritis, rheumatoid arthritis/ankylosing arthritis, or multiple sclerosis, during the follow-up period from 1993 to March 2018. The primary hypothesis is that "the risk of CID will be significantly higher among those with a low fibre/high red and processed meat intake compared to those with a high fibre/low red and processed meat intake." Based on previous research on a shared etiology in CIDs a second hypothesis is that "the postulated causality between low fibre/high red and processed meat intake and risk of developing CID is applicable for each of the CID-diagnoses." The core study is an open register-based cohort study. The study does not need approval from the local Ethics committee or Institutional Review Board by Danish law. The study was approved by the Danish Data Protection Agency (2012-58-0018) Study findings will be disseminated through peer-reviewed journals, patient associations and presentations at international conferences.

NCT ID: NCT03177655 Completed - Clinical trials for Multiple Sclerosis (MS)

Effect of Guided Imagery on Well-being in Patients With Multiple Sclerosis

HLGI
Start date: March 1, 2012
Phase: N/A
Study type: Interventional

This single-center interventional study quasi-randomly allocated patients to a guided imagery or control intervention (positive journaling). Data were analyzed with treatment allocation masked.

NCT ID: NCT03135249 Completed - Clinical trials for Multiple Sclerosis (MS)

Sequential Natalizumab - Alemtuzumab Therapy in Patients With Relapsing Forms of Multiple Sclerosis

SUPPRESS
Start date: May 1, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if a sequential combination therapy of natalizumab and alemtuzumab induces peripheral tolerance and reduces the annualized relapse rate (ARR) in patients with relapsing-remitting multiple sclerosis (RRMS).

NCT ID: NCT02739542 Completed - Clinical trials for Multiple Sclerosis (MS)

Assessment of Tecfidera® in Radiologically Isolated Syndrome (RIS)

ARISE
Start date: March 19, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this investigation is to systematically study the efficacy of Tecfidera in those individuals who possess incidental white matter anomalies within the brain following a MRI study that is performed for a reason other than for the evaluation of MS (multiple sclerosis).

NCT ID: NCT02695394 Completed - Clinical trials for Multiple Sclerosis (MS)

Emotional Processing in Multiple Sclerosis / Clinically Isolated Syndrome: A Neuropsychological fMRI-study

Start date: February 2016
Phase:
Study type: Observational

The aim of this prospective non-interventional neuropsychological one visit study involving functional MRI (fMRI) is to ascertain emotional processing in patients with Multiple Sclerosis (MS) or Clinically Isolated Syndrome (CIS) compared to healthy control subjects. In different experiments, the modulation of cognitive and motor responses by visual emotional information and the ability to discriminate visual emotional stimuli will be tested using experimental behavioral paradigms. Furthermore, functional connectivity and - using fMRI - activations of brain regions known to be involved with emotional processing will be evaluated.

NCT ID: NCT02612935 Completed - Clinical trials for Multiple Sclerosis (MS)

An Observational Pilot Study of Lumosity Computerized Cognitive Training in Subjects With Multiple Sclerosis

Start date: March 2015
Phase: N/A
Study type: Observational

In collaboration with the Mercy MS Achievement Center, Lumos Labs is proposing an open-label, 12-month pilot study of computerized cognitive training as part of the cognitive wellness program in order to evaluate (1) the user experience of Lumosity in individuals with MS, and (2) the efficacy of Lumosity for improving cognitive outcomes in individuals with MS.

NCT ID: NCT02352194 Recruiting - Clinical trials for Multiple Sclerosis (MS)

Physical Capacity and Rehabilitation of Patients With Multiple Sclerosis

REHABSEP
Start date: July 2014
Phase: N/A
Study type: Observational

The purpose of this study is to assess the physical capacity of patients with multiple sclerosis and the effects of rehabilitation, encompassing physical therapy and physical activity as it is carried out in the day hospital of (the Physical and Rehabilitation Medicine department) at Garches Hospital. We will compare the results of assessments carried out before and after a standard rehabilitation program.

NCT ID: NCT02308579 Completed - Clinical trials for Multiple Sclerosis (MS)

Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases

Start date: July 2014
Phase: N/A
Study type: Observational

This a retrospective, blinded trial in which collaborators in Italy will review the doppler findings from the Combined Transcranial and Extracranial Venous Doppler (CTEVD) trial in an attempt to measure reproducibility.

NCT ID: NCT02166021 Completed - Clinical trials for Multiple Sclerosis (MS)

Clinical Efficacy of Autologous Mesenchymal Bone Marrow Stem Cells in Active & Progressive Multiple Sclerosis

Start date: January 29, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the clinical efficacy and the optimal way of administration of autologous mesenchymal bone marrow stem cells (MSC) compering intravenous injection and intrathecal injection vs. placebo, in active-progressive Multiple Sclerosis patients.

NCT ID: NCT02019927 Completed - Trauma Clinical Trials

Electric Stimulation of the Eye to Improve Vision After Trauma

TES
Start date: July 2013
Phase: N/A
Study type: Interventional

Transcorneal Electrical Stimulation (TES) using the "OkuStim®" device delivers electrical impulses to damaged and/or diseased photoreceptor cells. This electric stimulation of the retina may help to preserve visual acuity and/or the visual field.