Clinical Trials Logo
  1. Home
  2. Multiple Organ Failure
  3. NCT02906345

TPE in Septic Patients and Influence on Organ Failure — TPEMOF  

Multiple Organ Failure Clinical Trial

Official title:
"Analyses on the Effectiveness and Technical Optimization of Therapeutic Plasma Exchange for Patients With Septic Shock, With Special Emphasis on Influencing the Kidney, Liver and Nervous System Through the Extracorporeal Therapy"

Clinical Trial Summary

Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.

Clinical Trial Description

Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study.

Investigators will study three groups:

1. untreated control group;

2. TPE group, plasma separation carried out by filtration;

3. TPE group, plasma separation carried out by centrifugation.

All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma. The study will focusing on the organ functions of the patients, especially liver-, kidney- and nervous function and also displayed in the SOFA score on study days 3 and 7. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02906345
Study type Interventional
Source University of Rostock
Contact Martin Sauer, MD
Phone 493814946409
Email martin.sauer@uni-rostock.de
Status Recruiting
Phase N/A
Start date September 2016
Completion date August 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT01937676 - LDH as a Biochemical Biomarker to Predict Organ Failure in the Emergency Department Setting N/A
Not yet recruiting NCT04356300 - Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection N/A
Terminated NCT03895853 - Early Metabolic Resuscitation for Septic Shock Phase 2
Recruiting NCT04094428 - Burden, Mortality and Supply Costs in Intensive Care Unit Patients
Recruiting NCT02587273 - The Pharmacokinetics of Fentanyl in Intensive Care Patients Phase 4
Recruiting NCT02265419 - Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients N/A
Completed NCT01810328 - A Validation of a Genomics Based Prognostic in Severe Trauma N/A
Not yet recruiting NCT06371677 - Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units
Recruiting NCT05182723 - Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation N/A
Completed NCT00257231 - Inflammation and the Host Response to Injury (Trauma)
Recruiting NCT04306419 - Observational Trial on Cytokine Adsorption in Sepsis
Completed NCT02998931 - Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients Phase 3
Not yet recruiting NCT01828372 - Quantification of Drugs and Their Degradation Products N/A
Completed NCT00118664 - Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children N/A
Completed NCT02706314 - Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Completed NCT02455180 - Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients Phase 4
Recruiting NCT02095444 - Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Phase 1/Phase 2
Active, not recruiting NCT02858778 - Timing of Acute Palliative Care Consultation in Critically Ill Patients N/A
Recruiting NCT01363635 - Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Completed NCT01423864 - Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome Phase 2