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NCT05968417 Clinical Trial

Myeloma Novel Drug Discovery Ver 1.2

Multiple Myeloma Clinical Trial

— DISCO  

Official title:
Investigation of the Activity of Novel Compounds for the Treatment of Myeloma and Mechanisms of Drug Resistance to Current Therapies

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05968417
Other study ID # CCR5106
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date July 22, 2020
Est. completion date February 28, 2035

Study information
Verified date August 2023
Source Institute of Cancer Research, United Kingdom
Contact Disco Team
Phone 020 3186 5275
Email Disco.iras263630@nhs.net
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Myeloma is a bone marrow cancer with over 5000 patients diagnosed in the UK each year. Researchers are committed to improving understanding of myeloma and developing more effective treatments with fewer side effects in order to improve patient outcomes. In order to do this, researchers are collecting samples of blood and bone marrow to test the activity of potential new treatments in the laboratory and to understand what may be the cause of some treatments not working.

Recruitment information / eligibility
Status Recruiting
Enrollment 250
Est. completion date February 28, 2035
Est. primary completion date February 28, 2033
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Participants who have a diagnosis, or suspected diagnosis, of myeloma or related plasma cell disorder 2. Participants who are undergoing a peripheral blood or bone marrow aspirate sampling for diagnostic, staging or follow-up purposes, before, whilst or after receiving anti-myeloma treatment 3. Participants aged 18 years of age or above 4. Participants willing to consent to an additional sample being taken at the time of their peripheral blood or bone marrow aspirate sampling Exclusion Criteria: 1. Participants unable to provide consent 2. Participants with known active infectious diseases (e.g. HIV, Hepatitis B/C, COVID) that pose a risk to the use of the sample in the laboratory

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Observational study - sample collection only.
No intervention - blood and/or bone marrow sample collection only

Locations
Country Name City State
United Kingdom The Royal Marsden NHS Foundation Trust London Borough of Sutton

Sponsors (2)
Lead Sponsor Collaborator
Institute of Cancer Research, United Kingdom Royal Marsden NHS Foundation Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cell viability Myeloma cell viability when incubated with standard of care and novel compounds. 12 months
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