Mecapegfilgrastim With Chemotherapy for Peripheral Blood Stem Cell Mobilization in MM and Lymphoma

Multiple Myeloma Clinical Trial

Official title:

A Prospective and Multicenter Clinical Study of Mecapegfilgrastim in Combination With Chemotherapy for Autologous Peripheral Blood Stem Cell Mobilization in Patients With Multiple Myeloma or Lymphoma

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05294055
• Other study ID #: MA-ASCT-II-002
• Status: Recruiting
• Phase: Phase 2
• Start date: April 26, 2022
• Est. completion date: September 30, 2024

Study information

• Verified date: December 2022
• Source: Institute of Hematology & Blood Diseases Hospital
• Contact: Wei Liu
• Phone: 86-022-23909282
• Email: liuwei[@]ihcams.ac.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a multicenter prospective study to evaluate the efficacy and safety of chemotherapy combined with a single dose of subcutaneous(SC) injection mecapegfilgrastim on day 2 or day 5 after chemotherapy for autologous peripheral blood stem cell (PBSC) mobilization in patients with multiple myeloma or lymphoma.

Description:

Subjects eligible for autologous stem-cell transplantation are randomized to receive a single dose of 12mg mecapegfilgrastim SC on day 2 or day 5 after chemotherapy for PBSC mobilization. According to the protocol, high-dose cyclophosphamide (50mg/kg or 2g/m2, for 2 days) is given to patients with MM, and high-dose etoposide (1.5-1.8g/m2, single dose ) is administered to patients with lymphoma. Apheresis is performed according to the standard institutional regulations. The primary point is to evaluate the percentage of successful mobilization, defined as the cumulative collection of ≥2×10^6/kg CD34+ cells in three or fewer apheresis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: September 30, 2024
• Est. primary completion date: March 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Lymphoma patients with =2 lines of prior therapy, patients with multiple myeloma with one line of therapy;

2. Patients who had achieved at least partial response (PR);

3. Patients who were eligible for autologous peripheral blood stem cell transplantation

4. Age=18 and=65 years;

5. Patients with Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

6. Patients who have an estimated life expectancy of more than three months

7. Fertile patients must be willing to use reliable contraception during the clinical study period and for 90 days after the last dose and have a negative serological pregnancy test within 72 hours prior to the first dose.

8. Patients must be able and willing to give written informed consent prior to any study-related procedures

Exclusion Criteria:

1. Patients who had previously attempted hematopoietic stem cell mobilization;

2. Patients who had undergone previous bone marrow transplantation;

3. Lymphoma patients with bone marrow involvement or patients with MM who had >10% bone marrow involvement at screening ;

4. Patients with angina pectoris, myocardial infarction, coronary stent implantation, uncontrolled arrhythmias (atrial tachycardia, atrial fibrillation, persistent ventricular arrhythmias, etc.), cardiac insufficiency, Q-Tc interval >500ms, left ventricular ejection fraction (EF)<60%, or other heart diseases that the investigator considers unsuitable for hematopoietic stem cell mobilization or hematopoietic stem cell transplantation;

5. Patients with uncontrolled pulmonary infection;

6. Patients who had any of the following laboratory indicators:

1. White blood cell count(WBC)<2.5×109/L;

2. Absolute neutrophil count(ANC)<1.5×109/L;

3. Platelets count(PLT)<80×109/L;

4. Creatinine > 2.0 X ULN of the reference range or creatinine clearance =60ml/min

5. AST/ALT/Total bilirubin > 2.5 X ULN;

7. Patients who have received any of the following treatments:

1. Patients who had been treated with more than 4 cycles of lenalidomide or received lenalidomide within 4 weeks prior to hematopoietic stem cell mobilization chemotherapy.

2. Patients who previously been treated with fludarabine or melphalan;

3. Patients who plan to receive radiation within 30 days after transplantation

4. Patients who had received radiation therapy in the pelvis

8. Patients allergic to Mecapegfilgrastim, pegylated granulocyte stimulating factor, granulocyte stimulating factor, or other formulations expressed by E. coli.

9. Patients who are pregnant or breastfeeding

10. Patients who are participating in other clinical studies or the interval of the last dose of prior study drug to the mobilization chemotherapy is less than 4 weeks (or 5 half-lives of the study drug);

11. Patients with other conditions unsuitable for this study according to the investigator's judgment.

Related Conditions & MeSH terms

• Lymphoma
• Multiple Myeloma
• Neoplasms, Plasma Cell

Intervention

Drug:
• Etoposide
Etoposide 1.5-1.8g/m2, single dose
• Cyclophosphamide
Cyclophosphamide 50mg/kg or 2g/m2, for 2 days
• Mecapegfilgrastim, day 2
Mecapegfilgrastim 12mg SC, on day 2 after chemotherapy
• Mecapegfilgrastim, day 5
Mecapegfilgrastim 12mg SC, on day 5 after chemotherapy

Locations

Country	Name	City	State
China	Peking University Third Hospital	Beijing	Beijing
China	Anhui Provincial Hospital	Hefei	Anhui
China	Shandong Cancer Hospital	Jinan	Shandong
China	Institute of Hematology & Blood Diseases Hospital	Tianjin	Tianjin
China	Tianjin Medical University Cancer Institute & Hospital	Tianjin	Tianjin
China	Tianjin Medical University General Hospital	Tianjin	Tianjin
China	Henan Cancer Hospital	Zhengzhou	Henan

Sponsors (2)

Lead Sponsor	Collaborator
Qiu Lugui	Jiangsu Hengrui Pharmaceuticals Co.,Ltd

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	percentage of successful mobilization	The percentage of subjects with =2×106 cell/kg CD34+ cells were collected.	up to 28 days since the last subject were given mecapegfilgrastim
Secondary	the number of the total CD34+ cells	the number of the total CD34+ cells which were collected from each subject	up to 28 days since the last subject were given mecapegfilgrastim
Secondary	the number of leukaphereses	the number of leukaphereses needed to collect =2×10^6/kg CD34+ cells	up to 28 days since the last subject were given mecapegfilgrastim
Secondary	Incidence of febrile neutropenia (FN)	incidence of FN during chemotherapy plus mecapegfilgrastim mobilization	up to 28 days since the last subject were given mecapegfilgrastim
Secondary	times to neutrophil and platelet engraftment	times to neutrophil and platelet engraftment after autologous stem cell transplantation	up to 1 year post-transplantation