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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05113342
Other study ID # DC25-1A
Secondary ID
Status Recruiting
Phase Phase 1/Phase 2
First received
Last updated
Start date November 25, 2021
Est. completion date December 2024

Study information

Verified date February 2024
Source Cartesian Therapeutics
Contact Hafsa Kamboh, MD
Phone 3013488698
Email Hafsa@cartesiantx.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This is a Phase I/IIa dose-escalation study to evaluate the safety, tolerability, and preliminary efficacy of an allogeneic Mesenchymal Stem Cell (Descartes-25) product secreting a bispecific protein and other proteins in patients with Relapsed/Refractory Multiple Myeloma.


Recruitment information / eligibility

Status Recruiting
Enrollment 20
Est. completion date December 2024
Est. primary completion date December 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - 18 years and older' - diagnosed with active R/RMM, who have failed 2 lines of treatment - have measurable disease Exclusion Criteria: - Patients with active plasma cell leukemia

Study Design


Intervention

Drug:
Descartes-25
allogeneic Mesenchymal Stem Cell product.

Locations

Country Name City State
Turkey Saglik Bilimleri Universitesi Ankara Anatolia
United States Center for Cancer and Blood Disorders Bethesda Maryland
United States Louisiana State University Health Science Center at Shreveport Shreveport Louisiana

Sponsors (1)

Lead Sponsor Collaborator
Cartesian Therapeutics

Countries where clinical trial is conducted

United States,  Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary Maximum Tolerated Dose Dose Level at which no more than 20% of the patients treated have shown Dose-Limiting Toxicity. 1 Year
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