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Clinical Trial Summary

This study is a single-armed, open-label, multicenter Phase 1/2 study to evaluate the efficacy and safety of CT103A in subjects with relapsed and refractory MM.


Clinical Trial Description

Leukapheresis procedure will be performed to manufacture CT103A chimeric antigen receptor (CAR) modified T cells. Bridging therapy is allowed between PBMC collection and lymphodepletion. Lymphodepletion with fludarabine and cyclophosphamide was performed for three consecutive days. After 1-day rest, subjects will receive a single dose infusion of CT103A at 1.0 x 10^6 CAR+ T cells/Kg. Subjects will be followed in the study for a minimum of 2 years after CT103A infusion. Long-term follow-up for lentiviral vector safety will be followed for up to 15 years after CT103A infusion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05066646
Study type Interventional
Source Nanjing IASO Biotherapeutics Co.,Ltd
Contact Songbai Cai
Phone +86 025-58287610
Email [email protected]
Status Recruiting
Phase Phase 1/Phase 2
Start date April 1, 2020
Completion date June 2024

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