Tasquinimod for the Treatment of Relapsed or Refractory Myeloma

Status Recruiting

Clinical Trial Summary

This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma.

Clinical Trial Description

Tasquinimod has previously been studied as an anti-cancer agent in patients with other cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer that showed an improvement in radiographic progression-free survival. The side effect profile of tasquinimod is well-characterized based on this previous experience. This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). For both single agent tasquinimod and the combination of tasquinimod with IRd, exploratory expansion cohorts will be enrolled to preliminarily characterize the antimyeloma activity of each regimen. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04405167
Study type	Interventional
Source	University of Pennsylvania
Contact	Dan Vogl, MD
Phone	215-662-7140
Email	dan.vogl@pennmedicine.upenn.edu
Status	Recruiting
Phase	Phase 1
Start date	July 10, 2020
Completion date	July 2025

View Details

See also
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