BCMA-directed CAR-T Cell Therapy in Adult Patients With Multiple Myeloma

Status Active, not recruiting

Clinical Trial Summary

This is a first-in-human study to evaluate the feasibility, safety and preliminary antitumor efficacy of autologous T cells genetically engineered with a novel B-cell Maturation Antigen (BCMA)-specific chimeric antigen receptor (CAR) and manufactured with a new process. CAR-T cells will be investigated as a single agent in multiple myeloma

Clinical Trial Description

This is a phase I, open label study to characterize the safety and tolerability of a novel B-cell Maturation Antigen (BCMA)-specific chimeric antigen receptor (CAR) manufactured with a new process. In the dose escalation part (Part A) of the study, the anti-BCMA CAR-T cell therapy will be studied in adult multiple myeloma (MM) subjects who are relapsed and/or refractory. In the dose evaluation part (Part B) of the study, the anti-BCMA CAR-T cell therapy will be studied in newly diagnosed adult subject with MM. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04318327
Study type	Interventional
Source	Novartis
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	July 23, 2020
Completion date	February 19, 2026

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See also
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