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Safety and Efficacy Assessments of Osalmid in Multiple Myeloma

Multiple Myeloma Clinical Trial

Official title:
Safety and Efficacy Assessments of Osalmid in the Treatment of Multiple Myeloma

Clinical Trial Summary

This study aims to evaluate the safety and efficacy of a traditional cholagogue drug osalmid, 2-hydroxy-N-(4-hydroxyphenyl)-benzamide, in the treatment of multiple myeloma (MM).

Clinical Trial Description

Osalmid, 2-hydroxy-N-(4-hydroxyphenyl)-benzamide, is a traditional cholagogue and is clinically used in China to promote biliary drainage and protect liver function. Studies have shown that osalmid is an inhibitor of ribonucleotide reductase (RR). Recently, it was proven by our group that osalmid induced a dose-dependent lethality in multiple myeloma (MM) cell lines H929, OPM2, U266, OCI-MY5, and RPMI 8266, as well as in MM xenograft mouse models. This study aims to assess the safety and efficacy of osalmid in the treatment of MM. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03670173
Study type Interventional
Source Shanghai 10th People's Hospital
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date October 1, 2018
Completion date May 18, 2021
View Details
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