Treatment of Primary Plasma Cell Leukaemia in Subjects Under the Age of 70

Multiple Myeloma Clinical Trial

— LPP  

Official title:

Treatment of Primary Plasma Cell Leukaemia in Subjects Under the Age of 70: Phase II Multicentre Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02858999
• Other study ID #: AOL09-DR-ROYER
• Status: Completed
• Phase: Phase 2
• First received: August 4, 2016
• Last updated: November 30, 2016
• Start date: January 2010
• Est. completion date: September 2016

Study information

• Verified date: November 2016
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé
• Study type: Interventional

Clinical Trial Summary

Plasma cell leukaemia is a rare variety of multiple myeloma with a poor prognosis. Plasma cell leukaemia is defined as: at least 2,000 circulating plasma cells per µL for a blood leukocyte count higher than 10,000/µL or 20% of plasma cells for a leukocyte count less than 10,000/µL. Plasma cell leukaemia can be either primary, when it constitutes the first manifestation of the disease, or secondary in the setting of relapsed/refractory multiple myeloma. Primary plasma cell leukaemia (PPL) is a rare disease, representing only 1 to 2% of all cases of multiple myelomas at diagnosis. As the annual incidence of multiple myeloma in France is about 4,000 new cases, an estimated 40 to 80 new cases of PPL would be observed each year.

Few data are currently available in the literature concerning the pathophysiology and therapeutic management of PPL, and are derived from retrospective series based small numbers of patients. The prognosis of PPL in response to conventional chemotherapy remains poor with a median survival of 7 to 14 months. However, longer survivals have been obtained with intensive therapy and haematopoietic stem cell transplantation (allogeneic or autologous HSCT).

The investigators propose to perform a prospective study of the management of patients with PPL under the age of 70 years, in combination with a laboratory study: 12 weeks of induction chemotherapy by liposomal Bortezomib-Dexamethasone-Doxorubicin (PAD) alternating with Bortezomib-Dexamethasone-Cyclophosphamide (VCD) for a total of 4 cycles. Peripheral blood stem cell collection after mobilization by G-CSF will be performed after high-dose Cyclophosphamide chemotherapy. Autologous HSCT conditioned by high-dose Melphalan will be performed during the following month for all responding patients. During the 3 months after this first autologous HSCT, allogeneic HSCT with attenuated conditioning will be proposed in patients under the age of 66 years in complete remission with a suitable donor, and another systematic autologous HSCT will be proposed in all other patients. For all patients not treated by allogeneic HSCT, consolidation/maintenance therapy will be performed 3 months after the second autologous HSCT: 4 quarterly consolidations with Bortezomib-Lenalidomide-Dexamethasone (VRD) with maintenance by 2 months of Lenalidomide between these cycles, for a total duration of one year.

The laboratory assessment will consist of blood and bone marrow samples systematically obtained at diagnosis for plasma cell phenotyping by cytometry, cytogenetics, FISH, study of the gene expression profile and SNParray. A DNA bank and plasma bank will be constituted. The investigators also propose to study residual disease by cytometry (after the first autologous HSCT, before and at the end of the consolidation/maintenance phase), as it increasingly appears to have a major impact on survival in multiple myeloma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: September 2016
• Est. primary completion date: July 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patient with primary plasma cell leukaemia corresponding to the International Myeloma Working Group definition.

• Patient not previously treated apart from a short course of corticosteroid therapy (dexamethasone 40 mg/day for 4 days).

• Age = 18 years and < 70 years.

• Patient able to provide signed informed consent.

• Effective contraception when justified (oral contraception/protected intercourse).

Exclusion Criteria:

• Consent not obtained.

• Patient under judicial protection, or permanent or temporary guardianship.

• Previously treated multiple myeloma, secondary plasma cell leukaemia.

• ECOG performance status > 2.

• History of severe psychiatric illness, severe renal failure not attributable to PPL, heart failure (ejection fraction < 40%), bilirubin > 3N, transaminases or gamma GT > 4N.

• Peripheral neuropathy > NCI grade 2.

• Contraindication to high-dose corticosteroids, cyclophosphamide and anthracyclines.

• Hypersensitivity to bortezomib or lenalidomide.

• Pregnant woman or nursing mothers.

• Malignant disease except for basal cell carcinoma or cervical carcinoma in situ.

• Positive HIV serology; active hepatitis B or C.

• Participation in a clinical trial during the 60 days prior to inclusion.

• Patient not covered by French national health insurance.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Leukemia
• Leukemia, Plasma Cell
• Multiple Myeloma

Intervention

Drug:
• PAD-VCD
12 weeks of induction chemotherapy by liposomal Bortezomib-Dexamethasone-Doxorubicin (PAD) alternating with Bortezomib-Dexamethasone-Cyclophosphamide (VCD) for a total of 4 cycles

Locations

Country	Name	City	State
France	CH Pays d'Aix	Aix-en-Provence
France	CHU Amiens	Amiens
France	CHU Besançon	Besançon
France	CHU Caen	Caen
France	CHU Clermont Ferrand	Clermont Ferrand
France	CHU Dijon	Dijon
France	CH Dunkerque	Dunkerque
France	CHRU Lille	Lille
France	Hospices Civils de Lyon	Lyon
France	CHU Nancy	Nancy
France	CHU Nantes	Nantes
France	CHU Nice	Nice
France	AP-HP	Paris
France	CHU Poitiers	Poitiers
France	CHU Rennes	Rennes
France	CHU Strasbourg	Strasbourg
France	CHU Toulouse	Toulouse
France	CHU Tours	Tours

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Disease-free survival		3 years	Yes