Multiple Myeloma Clinical Trial
Official title:
Molecular Analysis for Therapy Choice (MATCH)
| Verified date | April 2024 |
| Source | National Cancer Institute (NCI) |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and does not respond to treatment (refractory). Patients must have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
| Status | Active, not recruiting |
| Enrollment | 6452 |
| Est. completion date | December 31, 2025 |
| Est. primary completion date | December 31, 2025 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - ELIGIBILITY CRITERIA FOR SCREENING BIOPSY (STEP 0) - Patients must be >= 18 years of age. Because no dosing or adverse event data are currently available on the use of study investigational agents in patients < 18 years of age, children are excluded from this study - Patients of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to registration; patients that are pregnant or breast feeding are excluded; a patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: - Has achieved menarche at some point - Has not undergone a hysterectomy or bilateral oophorectomy; or - Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) - Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse prior to study entry, for the duration of study participation, and for 4 months after completion of study; should a patient or partner of the patient become pregnant or suspect a pregnancy while participating in this study, the treating physician should be informed immediately - Patients must have histologically documented solid tumors or histologically confirmed diagnosis of lymphoma or multiple myeloma requiring therapy and meet one of the following criteria: - Patients must have progressed following at least one line of standard systemic therapy and there must not be other approval/standard therapy available that has been shown to prolong overall survival (i.e. in a randomized trial against another standard treatment or by comparison to historical controls); patients who cannot receive other standard therapy that has been shown to prolong overall survival due to medical issues will be eligible, if other eligibility criteria are met; if the patient is currently receiving therapy, the clinician must have assessed that the current therapy is no longer benefitting the patient prior to enrolling on MATCH, regardless of whether it is considered standard OR - Patients for whose disease no standard treatment exists that has been shown to prolong overall survival - NOTE: No other prior malignancy is allowed except for the following: - Adequately treated basal cell or squamous cell skin cancer - In situ cervical cancer - Adequately treated stage I or II cancer from which the patient is currently in complete remission - Any other cancer from which the patient has been disease-free for 5 years - Patients must have measurable disease - Patients must meet the criteria below - Tumor tissue for the confirmation of "rare variant" by the MATCH assay is to be submitted, preferably from the same time of collection as that used to determine patient candidacy for treatment arm assignment - Registration to Step 0 must occur after stopping prior systemic anti-cancer therapy. There is no specific duration for which patients must be off treatment prior to registration to Step 0, as long as all eligibility criteria are met - Patients may have received other non-targeted, immunotherapy or targeted treatment between the prior genetic testing at the outside lab and registration to Step 0. The decision to stop such treatment in favor of participation in MATCH, if no further clinical benefit is expected, is per the treating physician's discretion. Documentation of a lack of response to the prior treatment is not required in these cases - Patients with an applicable "rare variant" must be able to meet the eligibility criteria for the appropriate subprotocols within 4 weeks following notification of treatment assignment - Patient meets one of the following criteria: - Patient is a candidate for Z1M based on local Clinical Laboratory Improvement Act (CLIA) assessment of mismatch repair deficiency (MMRd) by immunohistochemistry (IHC) or microsatellite instability (MSI) status by polymerase chain reaction (PCR), adequate tumor tissue is available for submission for mandatory central screening IHC and the patient will be able to meet the eligibility criteria for Z1M within 4 weeks following notification of treatment assignment OR - The sites have received results from one of the designated outside laboratories indicating a "rare variant" that is an actionable Mutation of Interest (aMOI) for specific select subprotocols - NOTE: There is no particular window of time after receiving the sequencing report notification of potential eligibility from an outside lab in which the patient must be registered to Step 0, but treatment slots will be assigned on a first come, first serve basis to those who do register to Step 0, and are not held for those notified of potential eligibility who do not register to Step 0 - NOTE: Treatment assignment (and the start of the associated deadline for Step 1 registration) may occur shortly after Step 0 registration. Note that certain "rare variant" arms require submission of archival tissue for central IHC testing to determine treatment assignment. For those arms, adequate tissue for the central IHC is required to be available for submission - NOTE: Other potential aMOIs that would be eligibility criteria for "NON RARE" arms, as determined by the designated laboratories, are not applicable for this process in MATCH - Patient must not require the use of full dose coumarin-derivative anticoagulants such as warfarin; low molecular weight heparin is permitted for prophylactic or therapeutic use; factor X inhibitors are permitted - NOTE: Warfarin may not be started while enrolled in the EAY131 study - Stopping the anticoagulation for biopsy should be per site standard operating procedure (SOP) - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 1 and a life expectancy of at least 3 months - Patients must not currently be receiving any other investigational agents - Patients must not have any uncontrolled intercurrent illness including, but not limited to: - Symptomatic congestive heart failure (New York Heart Association [NYHA] classification of III/IV) - Unstable angina pectoris or coronary angioplasty, or stenting within 6 months prior to registration to Step 0, 2, 4, 6 - Cardiac arrhythmia (ongoing cardiac dysrhythmias of National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version [v]4 grade >= 2) - Psychiatric illness/social situations that would limit compliance with study requirements - Intra-cardiac defibrillators - Known cardiac metastases - Abnormal cardiac valve morphology (>= grade 2) documented by echocardiogram (ECHO) (as clinically indicated); (subjects with grade 1 abnormalities [i.e., mild regurgitation/stenosis] can be entered on study); subjects with moderate valvular thickening should not be entered on study - NOTE: To receive an agent, patient must not have any uncontrolled intercurrent illness such as ongoing or active infection; patients with infections unlikely to be resolved within 2 weeks following screening should not be considered for the trial - Patients must be able to swallow tablets or capsules; a patient with any gastrointestinal disease that would impair ability to swallow, retain, or absorb drug is not eligible - Patients who are human immunodeficiency virus (HIV)-positive are eligible if: - CD4+ cell count greater or equal to 250 cells/mm^3 - If patient is on antiretroviral therapy, there must be minimal interactions or overlapping toxicity of the antiretroviral therapy with the experimental cancer treatment; for experimental cancer therapeutics with CYP3A/4 interactions, protease inhibitor therapy is disallowed; suggested regimens to replace protease inhibitor therapy include dolutegravir given with tenofovir/emtricitabine; raltegravir given with tenofovir and emtricitabine; once daily combinations that use pharmacologic boosters may not be used - No history of non-malignancy acquired immune deficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts - Probable long-term survival with HIV if cancer were not present - Any prior therapy, radiotherapy (except palliative radiation therapy of 30 gray [Gy] or less), or major surgery must have been completed >= 4 weeks prior to start of treatment; all adverse events due to prior therapy have resolved to a grade 1 or better (except alopecia and lymphopenia) by start of treatment; palliative radiation therapy must have been completed at least 2 weeks prior to start of treatment; the radiotherapy must not be to a lesion that is included as measurable disease - NOTE: Prostate cancer patients may continue their luteinizing hormone-releasing hormone (LHRH) agonist - NOTE: For patients entering the study via the original screening process, patients may receive non-protocol treatment after biopsy (if clinically indicated) until they receive notification of results; however, lack of response must be documented prior to registration to Step 1; new non-protocol treatment will NOT be permitted as intervening therapy after registration to Step 0; the only intervening treatment permitted is prior therapy that the patient already received prior to Step 0 registration; the decision to stop the intervening non-protocol treatment will be left up to the treating physician if patient has an aMOI; however, patients will need to be off such therapy for at least 4 weeks before receiving any MATCH protocol treatment - NOTE: For patients entering the study via a designated outside laboratory, no intervening systemic non-protocol treatment is permitted after Step 0 registration; all other eligibility requirements still apply to these patients, including the washouts for prior therapy noted above in this section, the time restrictions outlined, and the eligibility criteria for the intended subprotocol - Patients with brain metastases or primary brain tumors must have completed treatment, surgery or radiation therapy >= 4 weeks prior to start of treatment - Patients must have discontinued steroids >= 1 week prior to registration to Step 0 and remain off steroids thereafter, except as permitted; patients with glioblastoma (GBM) must have been on stable dose of steroids, or be off steroids, for one week prior to registration to treatment (Step 1, 3, 5, 7) - NOTE: The following steroids are permitted (low dose steroid use is defined as prednisone 10 mg daily or less, or bioequivalent dose of other corticosteroid): - Temporary steroid use: e.g. for CT imaging in setting of contrast allergy - Low dose steroid use for appetite - Chronic inhaled steroid use - Steroid injections for joint disease - Stable dose of replacement steroid for adrenal insufficiency or low doses for non-malignant disease - Topical steroid - Steroids required to manage toxicity related to study treatment, as described in the subprotocols - Steroids required as pre- or post-chemotherapy medication for acceptable intervening chemotherapy - NOTE: Steroids must be completed alongside last dose of chemotherapy - Leukocytes >= 3,000/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - Absolute neutrophil count (ANC) >= 1,500/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - Platelets >= 100,000/mcL (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - NOTE: Patients with documented bone marrow involvement by lymphoma are not required to meet the above hematologic parameters, but must have a platelet count of at least 75,000/mcL and neutrophil count of at least 1,000/mcL - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (unless documented Gilbert's syndrome, for which bilirubin =< 3 x institutional ULN is permitted) (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (up to 5 times ULN in presence of liver metastases) (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - Creatinine clearance >= 45 mL/min/1.73 m^2 for patients with creatinine levels above institutional ULN - As defined by the Cockcroft-Gault equation (within 2 weeks prior to screening step registration and within 4 weeks prior to treatment step registration) - Patients must have an electrocardiogram (ECG) within 8 weeks prior to registration to screening step and must meet the following cardiac criteria: - Resting corrected QT interval (QTc) =< 480 msec - NOTE: If the first recorded QTc exceeds 480 msec, two additional, consecutive ECGs are required and must result in a mean resting QTc =< 480 msec; it is recommended that there are 10-minute (+/- 5 minutes) breaks between the ECGs - The following only need to be assessed if the mean QTc > 480 msec - Check potassium and magnesium serum levels - Correct any identified hypokalemia and/or hypomagnesemia and may repeat ECG to confirm exclusion of patient due to QTc - For patients with heart rate (HR) 60-100 beats per minute (bpm), no manual read of QTc is required - For patients with baseline HR < 60 or > 100 bpm, manual read of QT by trained personnel is required, with Fridericia correction applied to determine QTc - Patient must not have hypokalemia (value < institutional lower limit of normal) - No factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age or any concomitant medication known to prolong the QT interval - NOTE: Patient must be taken off prohibited medication prior to registration to the screening step (Step 0, 2, 4, 6) and remain off these medications thereafter, unless permitted on a subprotocol for the management of treatment related toxicity; patient must be off the drug for at least 5 half-lives prior to registration to the treatment step (Step 1, 3, 5, 7); the medication half-life can be found in the package insert for Food and Drug Administration (FDA) approved drugs - ELIGIBILITY CRITERIA FOR FIRST TREATMENT (STEP 1) - NOTE: For patients entering step 0 with assay results from outside laboratories, no systemic treatment is allowed after step 0 registration - As MATCH is designed to add additional subprotocols, implement limited expansions of accrual for certain subprotocols, and/or amend existing arm-specific eligibility criteria, some patients entering under the original screening method may be eligible to have their results rerun in MATCHbox, even if they did not match to a treatment initially or did not receive a treatment assignment due to a lack of available assignment slots; patients whose sequence results will be rerun through MATCHbox must also meet the following criteria: - Samples must have been collected within 5 months of the activation of the addendum, as there is an additional month needed to get the patients on trial - Patient has not had treatment within the 5 months that resulted in a PR or better after the performance of the screening assessment - Patient must meet eligibility criteria, including performance status 1 or better and life expectancy of at least 3 months - Patients must meet the eligibility requirements with the following exceptions: - Patients may have received other non-targeted, immunotherapy or targeted treatment, which could be stopped in favor of returning to MATCH, if no response to the interim treatment has occurred and no further benefit is expected from this interim treatment, per the treating physician's discretion; documentation of a lack of response to the interim treatment is not required in these cases; however, the following restrictions apply: - Enrollment onto another investigational therapeutic study is not permitted - Patient cannot be responding to interim treatment, since the benefit of the MATCH treatment is unknown and may deprive patient of an effective treatment if it were given when a patient is responding to another treatment - NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their step 0 results will be re-interrogated to determine if another treatment is available - ELIGIBILITY CRITERIA FOR SECOND SCREENING (STEP 2) - Patient's disease has progressed on Step 1 treatment or patient could not tolerate assigned treatment - NOTE: PATIENTS ENTERING STEP 1 WITH A "RARE VARIANT" FROM AN "OUTSIDE" LAB ARE NOT ELIGIBLE FOR STEP 2 - No response and progression (or inability to tolerate further treatment) occurred < 6 months from start of step 1 treatment - NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their step 0 MATCH assay results will be re-interrogated to determine if another treatment is available upon registration to this study step; it is not necessary to confirm the availability of another potential treatment assignment in advance; only aMOIs detected by the MATCH assay may be used for the determination of eligibility to a relevant subprotocol OR - Progression (or inability to tolerate further treatment) occurred after a (1) response OR (2) after >= 6 months from start of step 1 treatment; patient must have tumor amenable to percutaneous biopsy and be willing and able to undergo a tumor biopsy or bone marrow aspirate for collection and submission of tumor tissue OR patient will be undergoing a procedure due to medical necessity during which the tissue may be collected for the central determination of the presence of one or more of the specific "actionable" mutations/amplifications of interest (aMOI); archived specimens cannot be accepted - Patients must meet eligibility criteria as defined in step 0 - Patient must not have been assigned to step 1 treatment based on a "rare variant" determined by a designated outside laboratory - ELIGIBILITY CRITERIA FOR SECOND TREATMENT (STEP 3) - NOTE: If screening biopsy samples were submitted during step 2, patients may receive non-protocol treatment after biopsy (if clinically indicated) until they receive notification of results however, lack of response must be documented prior to registration to step 3; new non-protocol treatment will NOT be permitted as intervening therapy after registration to step 2; the decision to stop the intervening nonprotocol treatment will be left up to the treating physician if patient has an aMOI; waiting periods as described will apply - ELIGIBILITY CRITERIA FOR THIRD SCREENING (STEP 4) - Patient's disease has progressed on step 3 treatment or patient could not tolerate assigned treatment - Patient must meet one of the following criteria: - No response and progression (or inability to tolerate further treatment) occurred < 6 months from start of step 3 (second) treatment AND a biopsy was performed at step 2 screening - NOTE: Patients meeting these criteria will NOT be biopsied at this time point; instead, their latest MATCH assay results will be re-interrogated to determine if another treatment is available upon registration to this study step; it is not necessary to confirm the availability of another potential treatment assignment in advance OR - Progression (or inability to tolerate further treatment) occurred on step 3 treatment and a biopsy was not performed at step 2 screening |
| Country | Name | City | State |
|---|---|---|---|
| Guam | FHP Health Center-Guam | Tamuning | |
| Puerto Rico | Cancer Center-Metro Medical Center Bayamon | Bayamon | |
| Puerto Rico | Doctors Cancer Center | Manati | |
| Puerto Rico | San Juan City Hospital | San Juan | |
| Puerto Rico | San Juan Community Oncology Group | San Juan | |
| United States | Hawaii Cancer Care - Westridge | 'Aiea | Hawaii |
| United States | Pali Momi Medical Center | 'Aiea | Hawaii |
| United States | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii |
| United States | Straub Pearlridge Clinic | 'Aiea | Hawaii |
| United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
| United States | The Queen's Medical Center - West Oahu | 'Ewa Beach | Hawaii |
| United States | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota |
| United States | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington |
| United States | Jefferson Abington Hospital | Abington | Pennsylvania |
| United States | Hickman Cancer Center | Adrian | Michigan |
| United States | Riverwood Healthcare Center | Aitkin | Minnesota |
| United States | Lovelace Medical Center-Downtown | Albuquerque | New Mexico |
| United States | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico |
| United States | Presbyterian Kaseman Hospital | Albuquerque | New Mexico |
| United States | Southwest Gynecologic Oncology Associates Inc | Albuquerque | New Mexico |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
| United States | Aultman Alliance Community Hospital | Alliance | Ohio |
| United States | Saint Anthony's Health | Alton | Illinois |
| United States | UPMC Altoona | Altoona | Pennsylvania |
| United States | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah |
| United States | Mary Greeley Medical Center | Ames | Iowa |
| United States | McFarland Clinic - Ames | Ames | Iowa |
| United States | Community Hospital of Anaconda | Anaconda | Montana |
| United States | Cancer Care Center at Island Hospital | Anacortes | Washington |
| United States | Kaiser Permanente-Anaheim | Anaheim | California |
| United States | Alaska Breast Care and Surgery LLC | Anchorage | Alaska |
| United States | Alaska Oncology and Hematology LLC | Anchorage | Alaska |
| United States | Alaska Regional Hospital | Anchorage | Alaska |
| United States | Alaska Women's Cancer Care | Anchorage | Alaska |
| United States | Anchorage Associates in Radiation Medicine | Anchorage | Alaska |
| United States | Anchorage Oncology Centre | Anchorage | Alaska |
| United States | Anchorage Radiation Therapy Center | Anchorage | Alaska |
| United States | Katmai Oncology Group | Anchorage | Alaska |
| United States | Providence Alaska Medical Center | Anchorage | Alaska |
| United States | AnMed Health Cancer Center | Anderson | South Carolina |
| United States | C S Mott Children's Hospital | Ann Arbor | Michigan |
| United States | Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan |
| United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
| United States | Luminis Health Anne Arundel Medical Center | Annapolis | Maryland |
| United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
| United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
| United States | Ascension Saint Elizabeth Hospital | Appleton | Wisconsin |
| United States | Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California |
| United States | PCR Oncology | Arroyo Grande | California |
| United States | AdventHealth Infusion Center Asheville | Asheville | North Carolina |
| United States | Hope Women's Cancer Centers-Asheville | Asheville | North Carolina |
| United States | Messino Cancer Centers | Asheville | North Carolina |
| United States | Mission Hospital | Asheville | North Carolina |
| United States | Duluth Clinic Ashland | Ashland | Wisconsin |
| United States | Northwest Wisconsin Cancer Center | Ashland | Wisconsin |
| United States | University Cancer and Blood Center LLC | Athens | Georgia |
| United States | Emory Saint Joseph's Hospital | Atlanta | Georgia |
| United States | Emory University Hospital Midtown | Atlanta | Georgia |
| United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
| United States | Northside Hospital | Atlanta | Georgia |
| United States | Piedmont Hospital | Atlanta | Georgia |
| United States | MultiCare Auburn Medical Center | Auburn | Washington |
| United States | Sutter Auburn Faith Hospital | Auburn | California |
| United States | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California |
| United States | Augusta University Medical Center | Augusta | Georgia |
| United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
| United States | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado |
| United States | Rush - Copley Medical Center | Aurora | Illinois |
| United States | The Medical Center of Aurora | Aurora | Colorado |
| United States | UCHealth University of Colorado Hospital | Aurora | Colorado |
| United States | Dell Seton Medical Center at The University of Texas | Austin | Texas |
| United States | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida |
| United States | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington |
| United States | Saint Alphonsus Cancer Care Center-Baker City | Baker City | Oregon |
| United States | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California |
| United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
| United States | Greater Baltimore Medical Center | Baltimore | Maryland |
| United States | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland |
| United States | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland |
| United States | MedStar Good Samaritan Hospital | Baltimore | Maryland |
| United States | MedStar Union Memorial Hospital | Baltimore | Maryland |
| United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
| United States | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland |
| United States | Eastern Maine Medical Center | Bangor | Maine |
| United States | Flaget Memorial Hospital | Bardstown | Kentucky |
| United States | Baton Rouge General Medical Center | Baton Rouge | Louisiana |
| United States | Hematology/Oncology Clinic PLLC | Baton Rouge | Louisiana |
| United States | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana |
| United States | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana |
| United States | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana |
| United States | Medical Center of Baton Rouge | Baton Rouge | Louisiana |
| United States | Ochsner Health Center-Summa | Baton Rouge | Louisiana |
| United States | Ochsner High Grove | Baton Rouge | Louisiana |
| United States | Our Lady of The Lake | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Medical Oncology | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Physician Group | Baton Rouge | Louisiana |
| United States | The NeuroMedical Center-Clinic | Baton Rouge | Louisiana |
| United States | Bronson Battle Creek | Battle Creek | Michigan |
| United States | Essentia Health - Baxter Clinic | Baxter | Minnesota |
| United States | South Shore University Hospital | Bay Shore | New York |
| United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
| United States | Beaufort Memorial Hospital | Beaufort | South Carolina |
| United States | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania |
| United States | Indu and Raj Soin Medical Center | Beavercreek | Ohio |
| United States | Waldo County General Hospital | Belfast | Maine |
| United States | Nebraska Medicine-Bellevue | Bellevue | Nebraska |
| United States | Overlake Medical Center | Bellevue | Washington |
| United States | Swedish Cancer Institute-Eastside Oncology Hematology | Bellevue | Washington |
| United States | Kaiser Permanente-Bellflower | Bellflower | California |
| United States | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington |
| United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
| United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
| United States | Saint Charles Health System | Bend | Oregon |
| United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
| United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
| United States | National Institutes of Health Clinical Center | Bethesda | Maryland |
| United States | Walter Reed National Military Medical Center | Bethesda | Maryland |
| United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
| United States | Beverly Hospital | Beverly | Massachusetts |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine |
| United States | Billings Clinic Cancer Center | Billings | Montana |
| United States | Saint Vincent Frontier Cancer Center | Billings | Montana |
| United States | Saint Vincent Healthcare | Billings | Montana |
| United States | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama |
| United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
| United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
| United States | OSF Saint Joseph Medical Center | Bloomington | Illinois |
| United States | Saint Elizabeth Boardman Hospital | Boardman | Ohio |
| United States | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina |
| United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
| United States | Saint Luke's Cancer Institute - Boise | Boise | Idaho |
| United States | Central Care Cancer Center - Bolivar | Bolivar | Missouri |
| United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
| United States | McFarland Clinic - Boone | Boone | Iowa |
| United States | Beth Israel Deaconess Medical Center | Boston | Massachusetts |
| United States | Boston Medical Center | Boston | Massachusetts |
| United States | Dana-Farber Cancer Institute | Boston | Massachusetts |
| United States | Massachusetts General Hospital Cancer Center | Boston | Massachusetts |
| United States | Tufts Medical Center | Boston | Massachusetts |
| United States | Boulder Community Foothills Hospital | Boulder | Colorado |
| United States | Boulder Community Hospital | Boulder | Colorado |
| United States | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado |
| United States | Bozeman Health Deaconess Hospital | Bozeman | Montana |
| United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
| United States | Cox Cancer Center Branson | Branson | Missouri |
| United States | Northeast Georgia Medical Center Braselton | Braselton | Georgia |
| United States | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington |
| United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
| United States | Ocean University Medical Center | Brick | New Jersey |
| United States | United Hospital Center | Bridgeport | West Virginia |
| United States | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan |
| United States | Trinity Health Medical Center - Brighton | Brighton | Michigan |
| United States | Children's Hospital at Montefiore | Bronx | New York |
| United States | Montefiore Medical Center - Moses Campus | Bronx | New York |
| United States | Montefiore Medical Center-Einstein Campus | Bronx | New York |
| United States | Montefiore Medical Center-Weiler Hospital | Bronx | New York |
| United States | Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin |
| United States | State University of New York Downstate Medical Center | Brooklyn | New York |
| United States | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan |
| United States | Saint Joseph Regional Cancer Center | Bryan | Texas |
| United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
| United States | Roswell Park Cancer Institute | Buffalo | New York |
| United States | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California |
| United States | Highline Medical Center-Main Campus | Burien | Washington |
| United States | Mills-Peninsula Medical Center | Burlingame | California |
| United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
| United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
| United States | University of Vermont and State Agricultural College | Burlington | Vermont |
| United States | University of Vermont Medical Center | Burlington | Vermont |
| United States | Fairview Ridges Hospital | Burnsville | Minnesota |
| United States | Minnesota Oncology - Burnsville | Burnsville | Minnesota |
| United States | UPMC Hillman Cancer Center at Butler Health System | Butler | Pennsylvania |
| United States | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana |
| United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
| United States | Cambridge Medical Center | Cambridge | Minnesota |
| United States | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California |
| United States | UPMC Camp Hill | Camp Hill | Pennsylvania |
| United States | Aultman Health Foundation | Canton | Ohio |
| United States | Cleveland Clinic Mercy Hospital | Canton | Ohio |
| United States | Illinois CancerCare-Canton | Canton | Illinois |
| United States | Mercy Hematology and Oncology Associates Inc | Canton | Ohio |
| United States | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan |
| United States | Trinity Health Medical Center - Canton | Canton | Michigan |
| United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
| United States | Southeast Cancer Center | Cape Girardeau | Missouri |
| United States | AtlantiCare Health Park-Cape May Court House | Cape May Court House | New Jersey |
| United States | Memorial Hospital of Carbondale | Carbondale | Illinois |
| United States | Carlisle Regional Cancer Center | Carlisle | Pennsylvania |
| United States | Caro Cancer Center | Caro | Michigan |
| United States | Saint Anthony Regional Hospital | Carroll | Iowa |
| United States | Carson Tahoe Regional Medical Center | Carson City | Nevada |
| United States | SIH Cancer Institute | Carterville | Illinois |
| United States | Illinois CancerCare-Carthage | Carthage | Illinois |
| United States | Waverly Hematology Oncology | Cary | North Carolina |
| United States | Eden Hospital Medical Center | Castro Valley | California |
| United States | Sandra L Maxwell Cancer Center | Cedar City | Utah |
| United States | Mercy Hospital | Cedar Rapids | Iowa |
| United States | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa |
| United States | Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa |
| United States | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado |
| United States | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio |
| United States | Miami Valley Hospital South | Centerville | Ohio |
| United States | Centralia Oncology Clinic | Centralia | Illinois |
| United States | Providence Regional Cancer System-Centralia | Centralia | Washington |
| United States | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania |
| United States | Chambersburg Hospital | Chambersburg | Pennsylvania |
| United States | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina |
| United States | Geauga Hospital | Chardon | Ohio |
| United States | Bon Secours Saint Francis Hospital | Charleston | South Carolina |
| United States | Charleston Oncology - Roper | Charleston | South Carolina |
| United States | Charleston Oncology - Saint Francis | Charleston | South Carolina |
| United States | Lowcountry Hematology Oncology PA-North Charleston | Charleston | South Carolina |
| United States | Lowcountry Hematology Oncology PA-West Ashley | Charleston | South Carolina |
| United States | Medical University of South Carolina | Charleston | South Carolina |
| United States | Roper Hospital | Charleston | South Carolina |
| United States | West Virginia University Charleston Division | Charleston | West Virginia |
| United States | Novant Health Carolina Surgical - Randolph | Charlotte | North Carolina |
| United States | Novant Health Presbyterian Medical Center | Charlotte | North Carolina |
| United States | Oncology Specialists of Charlotte | Charlotte | North Carolina |
| United States | Southern Oncology Specialists-Charlotte | Charlotte | North Carolina |
| United States | Memorial Hospital | Chattanooga | Tennessee |
| United States | Chelsea Hospital | Chelsea | Michigan |
| United States | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan |
| United States | Saint Luke's Hospital | Chesterfield | Missouri |
| United States | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming |
| United States | Advocate Illinois Masonic Medical Center | Chicago | Illinois |
| United States | John H Stroger Jr Hospital of Cook County | Chicago | Illinois |
| United States | Mount Sinai Hospital Medical Center | Chicago | Illinois |
| United States | Northwestern University | Chicago | Illinois |
| United States | Rush University Medical Center | Chicago | Illinois |
| United States | Swedish Covenant Hospital | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | University of Illinois | Chicago | Illinois |
| United States | Adena Regional Medical Center | Chillicothe | Ohio |
| United States | Ascension Calumet Hospital | Chilton | Wisconsin |
| United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
| United States | Bethesda North Hospital | Cincinnati | Ohio |
| United States | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio |
| United States | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Anderson | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio |
| United States | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio |
| United States | The Christ Hospital | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio |
| United States | TriHealth Cancer Institute-Westside | Cincinnati | Ohio |
| United States | Clackamas Radiation Oncology Center | Clackamas | Oregon |
| United States | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon |
| United States | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan |
| United States | Newland Medical Associates-Clarkston | Clarkston | Michigan |
| United States | Case Western Reserve University | Cleveland | Ohio |
| United States | Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | MetroHealth Medical Center | Cleveland | Ohio |
| United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
| United States | Henry Ford Hematology Oncology - Hayes | Clinton Township | Michigan |
| United States | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan |
| United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
| United States | Mission Cancer and Blood - West Des Moines | Clive | Iowa |
| United States | Community Cancer Institute | Clovis | California |
| United States | University Oncology Associates | Clovis | California |
| United States | AdventHealth Infusion Center Haywood | Clyde | North Carolina |
| United States | Big Horn Basin Cancer Center | Cody | Wyoming |
| United States | Billings Clinic-Cody | Cody | Wyoming |
| United States | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho |
| United States | Coffeyville Regional Medical Center | Coffeyville | Kansas |
| United States | Main Line Health Center-Collegeville | Collegeville | Pennsylvania |
| United States | Integrity Oncology PLLC-Collierville | Collierville | Tennessee |
| United States | Memorial Hospital North | Colorado Springs | Colorado |
| United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
| United States | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado |
| United States | Saint Francis Cancer Center | Colorado Springs | Colorado |
| United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
| United States | MU Health - University Hospital/Ellis Fischel Cancer Center | Columbia | Missouri |
| United States | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi |
| United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
| United States | Doctors Hospital | Columbus | Ohio |
| United States | Grant Medical Center | Columbus | Ohio |
| United States | John B Amos Cancer Center | Columbus | Georgia |
| United States | Mount Carmel East Hospital | Columbus | Ohio |
| United States | Mount Carmel Health Center West | Columbus | Ohio |
| United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
| United States | Riverside Methodist Hospital | Columbus | Ohio |
| United States | The Mark H Zangmeister Center | Columbus | Ohio |
| United States | John Muir Medical Center-Concord | Concord | California |
| United States | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire |
| United States | MD Anderson in The Woodlands | Conroe | Texas |
| United States | Cookeville Regional Medical Center | Cookeville | Tennessee |
| United States | Mercy Hospital | Coon Rapids | Minnesota |
| United States | Bay Area Hospital | Coos Bay | Oregon |
| United States | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs | Florida |
| United States | Baptist Health Corbin | Corbin | Kentucky |
| United States | Commonwealth Cancer Center-Corbin | Corbin | Kentucky |
| United States | City of Hope Corona | Corona | California |
| United States | Good Samaritan Hospital | Corvallis | Oregon |
| United States | UC Irvine Health Cancer Center-Newport | Costa Mesa | California |
| United States | Alegent Health Mercy Hospital | Council Bluffs | Iowa |
| United States | Heartland Oncology and Hematology LLP | Council Bluffs | Iowa |
| United States | Methodist Jennie Edmundson Hospital | Council Bluffs | Iowa |
| United States | Mary Bird Perkins Cancer Center - Covington | Covington | Louisiana |
| United States | Northshore Oncology Associates-Covington | Covington | Louisiana |
| United States | Ochsner Hematology Oncology North Shore - Covington (West Region) | Covington | Louisiana |
| United States | Women's Cancer Care-Covington | Covington | Louisiana |
| United States | UPMC Hillman Cancer Center - Passavant - Cranberry | Cranberry Township | Pennsylvania |
| United States | Greater Regional Medical Center | Creston | Iowa |
| United States | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky |
| United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
| United States | Michiana Hematology Oncology PC-Crown Point | Crown Point | Indiana |
| United States | AMG Crystal Lake - Oncology | Crystal Lake | Illinois |
| United States | Aurora Saint Luke's South Shore | Cudahy | Wisconsin |
| United States | UPMC Western Maryland | Cumberland | Maryland |
| United States | Northside Hospital-Forsyth | Cumming | Georgia |
| United States | Baylor University Medical Center | Dallas | Texas |
| United States | Parkland Memorial Hospital | Dallas | Texas |
| United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
| United States | Carle at The Riverfront | Danville | Illinois |
| United States | Danville Regional Medical Center | Danville | Virginia |
| United States | Geisinger Medical Center | Danville | Pennsylvania |
| United States | Sutter Davis Hospital | Davis | California |
| United States | Dayton Physician LLC - Englewood | Dayton | Ohio |
| United States | Good Samaritan Hospital - Dayton | Dayton | Ohio |
| United States | Miami Valley Hospital | Dayton | Ohio |
| United States | Miami Valley Hospital North | Dayton | Ohio |
| United States | Beaumont Hospital - Dearborn | Dearborn | Michigan |
| United States | Henry Ford Medical Center-Fairlane | Dearborn | Michigan |
| United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | Dekalb Medical Center | Decatur | Georgia |
| United States | Essentia Health - Deer River Clinic | Deer River | Minnesota |
| United States | Broward Health North | Deerfield Beach | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida |
| United States | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois |
| United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
| United States | Delaware Radiation Oncology | Delaware | Ohio |
| United States | Grady Memorial Hospital | Delaware | Ohio |
| United States | Cancer Center of Colorado at Sloan's Lake | Denver | Colorado |
| United States | Colorado Blood Cancer Institute | Denver | Colorado |
| United States | Denver Health Medical Center | Denver | Colorado |
| United States | Kaiser Permanente-Franklin | Denver | Colorado |
| United States | National Jewish Health-Main Campus | Denver | Colorado |
| United States | Porter Adventist Hospital | Denver | Colorado |
| United States | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado |
| United States | Rocky Mountain Cancer Centers-Rose | Denver | Colorado |
| United States | Rose Medical Center | Denver | Colorado |
| United States | SCL Health Saint Joseph Hospital | Denver | Colorado |
| United States | The Women's Imaging Center | Denver | Colorado |
| United States | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut |
| United States | Broadlawns Medical Center | Des Moines | Iowa |
| United States | Iowa Lutheran Hospital | Des Moines | Iowa |
| United States | Iowa Methodist Medical Center | Des Moines | Iowa |
| United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
| United States | Mission Cancer and Blood - Des Moines | Des Moines | Iowa |
| United States | Mission Cancer and Blood - Laurel | Des Moines | Iowa |
| United States | Ascension Saint John Hospital | Detroit | Michigan |
| United States | Henry Ford Hospital | Detroit | Michigan |
| United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
| United States | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota |
| United States | Illinois CancerCare-Dixon | Dixon | Illinois |
| United States | Doylestown Hospital | Doylestown | Pennsylvania |
| United States | City of Hope Comprehensive Cancer Center | Duarte | California |
| United States | Columbus Oncology and Hematology Associates | Dublin | Ohio |
| United States | Dublin Methodist Hospital | Dublin | Ohio |
| United States | Epic Care-Dublin | Dublin | California |
| United States | Kaiser Permanente Dublin | Dublin | California |
| United States | Essentia Health Cancer Center | Duluth | Minnesota |
| United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
| United States | Miller-Dwan Hospital | Duluth | Minnesota |
| United States | Northside Hospital - Duluth | Duluth | Georgia |
| United States | Mercy Medical Center | Durango | Colorado |
| United States | Southwest Oncology PC | Durango | Colorado |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Durham VA Medical Center | Durham | North Carolina |
| United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
| United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
| United States | Michigan State University Clinical Center | East Lansing | Michigan |
| United States | Pocono Medical Center | East Stroudsburg | Pennsylvania |
| United States | Easton Hospital | Easton | Pennsylvania |
| United States | University of Maryland Shore Medical Center at Easton | Easton | Maryland |
| United States | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin |
| United States | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin |
| United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
| United States | Saint Elizabeth Healthcare Edgewood | Edgewood | Kentucky |
| United States | Fairview Southdale Hospital | Edina | Minnesota |
| United States | Swedish Cancer Institute-Edmonds | Edmonds | Washington |
| United States | Carle Physician Group-Effingham | Effingham | Illinois |
| United States | Crossroads Cancer Center | Effingham | Illinois |
| United States | AtlantiCare Surgery Center | Egg Harbor Township | New Jersey |
| United States | Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus | Elizabeth | New Jersey |
| United States | Baptist Health Hardin | Elizabethtown | Kentucky |
| United States | Ascension Alexian Brothers - Elk Grove Village | Elk Grove Village | Illinois |
| United States | Michiana Hematology Oncology PC-Elkhart | Elkhart | Indiana |
| United States | Christiana Care - Union Hospital | Elkton | Maryland |
| United States | Elmhurst Memorial Hospital | Elmhurst | Illinois |
| United States | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York |
| United States | Essentia Health - Ely Clinic | Ely | Minnesota |
| United States | Hematology Oncology Center Incorporated | Elyria | Ohio |
| United States | Mercy Cancer Center-Elyria | Elyria | Ohio |
| United States | Bay Area Breast Surgeons Inc | Emeryville | California |
| United States | Epic Care Partners in Cancer Care | Emeryville | California |
| United States | Walter Knox Memorial Hospital | Emmett | Idaho |
| United States | Newman Regional Health | Emporia | Kansas |
| United States | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado |
| United States | Rocky Mountain Cancer Centers - Swedish | Englewood | Colorado |
| United States | Swedish Medical Center | Englewood | Colorado |
| United States | Saint Elizabeth Hospital | Enumclaw | Washington |
| United States | Ephrata Cancer Center | Ephrata | Pennsylvania |
| United States | Ephrata Community Hospital | Ephrata | Pennsylvania |
| United States | UPMC Hamot | Erie | Pennsylvania |
| United States | UPMC Hillman Cancer Center Erie | Erie | Pennsylvania |
| United States | OSF Saint Francis Hospital and Medical Group | Escanaba | Michigan |
| United States | Illinois CancerCare-Eureka | Eureka | Illinois |
| United States | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois |
| United States | Saint Francis Hospital | Evanston | Illinois |
| United States | Deaconess Clinic Downtown | Evansville | Indiana |
| United States | Providence Regional Cancer Partnership | Everett | Washington |
| United States | Main Line Health Center-Exton | Exton | Pennsylvania |
| United States | Fairbanks Memorial Hospital | Fairbanks | Alaska |
| United States | Inova Fair Oaks Hospital | Fairfax | Virginia |
| United States | Inova Schar Cancer Institute | Fairfax | Virginia |
| United States | JCHC McCreery Cancer Center | Fairfield | Iowa |
| United States | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio |
| United States | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut |
| United States | Thomas Hospital | Fairhope | Alabama |
| United States | University of Kansas Clinical Research Center | Fairway | Kansas |
| United States | Inova Fairfax Hospital | Falls Church | Virginia |
| United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Sanford Clinic North-Fargo | Fargo | North Dakota |
| United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
| United States | Sanford South University Medical Center | Fargo | North Dakota |
| United States | Farmington Health Center | Farmington | Utah |
| United States | Parkland Health Center - Farmington | Farmington | Missouri |
| United States | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan |
| United States | UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania |
| United States | Saint Francis Hospital | Federal Way | Washington |
| United States | Virginia Mason Federal Way Medical Center | Federal Way | Washington |
| United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
| United States | Armes Family Cancer Center | Findlay | Ohio |
| United States | Blanchard Valley Hospital | Findlay | Ohio |
| United States | Orion Cancer Care | Findlay | Ohio |
| United States | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia |
| United States | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts |
| United States | Hunterdon Medical Center | Flemington | New Jersey |
| United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
| United States | Genesee Hematology Oncology PC | Flint | Michigan |
| United States | Genesys Hurley Cancer Institute | Flint | Michigan |
| United States | Hurley Medical Center | Flint | Michigan |
| United States | McLeod Regional Medical Center | Florence | South Carolina |
| United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
| United States | Kaiser Permanente-Fontana | Fontana | California |
| United States | Poudre Valley Hospital | Fort Collins | Colorado |
| United States | McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa |
| United States | Trinity Regional Medical Center | Fort Dodge | Iowa |
| United States | Broward Health Medical Center | Fort Lauderdale | Florida |
| United States | Holy Cross Hospital | Fort Lauderdale | Florida |
| United States | Mercy Hospital Fort Smith | Fort Smith | Arkansas |
| United States | Saint Elizabeth Healthcare Fort Thomas | Fort Thomas | Kentucky |
| United States | UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas |
| United States | Essentia Health - Fosston | Fosston | Minnesota |
| United States | MetroWest Medical Center-Framingham Union Hospital | Framingham | Massachusetts |
| United States | Beebe South Coastal Health Campus | Frankford | Delaware |
| United States | Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin |
| United States | Ascension Southeast Wisconsin Hospital - Franklin | Franklin | Wisconsin |
| United States | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio |
| United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
| United States | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee |
| United States | FMH James M Stockman Cancer Institute | Frederick | Maryland |
| United States | Frederick Memorial Hospital | Frederick | Maryland |
| United States | Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia |
| United States | Kaiser Permanente-Fremont | Fremont | California |
| United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
| United States | Fresno Cancer Center | Fresno | California |
| United States | Kaiser Permanente-Fresno | Fresno | California |
| United States | Unity Hospital | Fridley | Minnesota |
| United States | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho |
| United States | Saint Jude Medical Center | Fullerton | California |
| United States | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina |
| United States | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia |
| United States | The Longstreet Clinic - Gainesville | Gainesville | Georgia |
| United States | University of Florida Health Science Center - Gainesville | Gainesville | Florida |
| United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
| United States | Western Illinois Cancer Treatment Center | Galesburg | Illinois |
| United States | Central Care Cancer Center - Garden City | Garden City | Kansas |
| United States | Saint Catherine Hospital | Garden City | Kansas |
| United States | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois |
| United States | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina |
| United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
| United States | Adams Cancer Center | Gettysburg | Pennsylvania |
| United States | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington |
| United States | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington |
| United States | Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Connecticut |
| United States | Glens Falls Hospital | Glens Falls | New York |
| United States | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois |
| United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
| United States | Mountain Blue Cancer Care Center | Golden | Colorado |
| United States | National Jewish Health-Western Hematology Oncology | Golden | Colorado |
| United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
| United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
| United States | CTCA at Western Regional Medical Center | Goodyear | Arizona |
| United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
| United States | Nebraska Cancer Specialists/Oncology Hematology West PC | Grand Island | Nebraska |
| United States | Grand Valley Oncology | Grand Junction | Colorado |
| United States | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado |
| United States | Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan |
| United States | Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital | Grand Rapids | Michigan |
| United States | Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan |
| United States | Central Care Cancer Center - Great Bend | Great Bend | Kansas |
| United States | Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas |
| United States | Benefis Sletten Cancer Institute | Great Falls | Montana |
| United States | Banner North Colorado Medical Center | Greeley | Colorado |
| United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
| United States | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin |
| United States | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | Marin Cancer Care Inc | Greenbrae | California |
| United States | Marin General Hospital | Greenbrae | California |
| United States | Novant Health Breast Surgery - Greensboro | Greensboro | North Carolina |
| United States | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania |
| United States | Dayton Physicians LLC-Wayne | Greenville | Ohio |
| United States | Greenville Health System Cancer Institute-Andrews | Greenville | South Carolina |
| United States | Oncology Hematology Associates | Greenville | Pennsylvania |
| United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
| United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
| United States | Saint Francis Cancer Center | Greenville | South Carolina |
| United States | Saint Francis Hospital | Greenville | South Carolina |
| United States | Wayne Hospital | Greenville | Ohio |
| United States | Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut |
| United States | Self Regional Healthcare | Greenwood | South Carolina |
| United States | Rocky Mountain Cancer Centers-Greenwood Village | Greenwood Village | Colorado |
| United States | Gibbs Cancer Center-Pelham | Greer | South Carolina |
| United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
| United States | Baptist Cancer Center-Grenada | Grenada | Mississippi |
| United States | Legacy Mount Hood Medical Center | Gresham | Oregon |
| United States | Ochsner Medical Center West Bank | Gretna | Louisiana |
| United States | William Beaumont Hospital-Grosse Pointe | Grosse Pointe | Michigan |
| United States | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan |
| United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
| United States | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan |
| United States | Mount Carmel Grove City Hospital | Grove City | Ohio |
| United States | Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut |
| United States | Hackensack University Medical Center | Hackensack | New Jersey |
| United States | WellSpan Medical Oncology and Hematology | Hanover | Pennsylvania |
| United States | Kaiser Permanente - Harbor City | Harbor City | California |
| United States | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania |
| United States | UPMC Pinnacle Harrisburg | Harrisburg | Pennsylvania |
| United States | Memorial Sloan Kettering Westchester | Harrison | New York |
| United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
| United States | Ingalls Memorial Hospital | Harvey | Illinois |
| United States | Forrest General Hospital / Cancer Center | Hattiesburg | Mississippi |
| United States | Hattiesburg Clinic - Hematology/Oncology Clinic | Hattiesburg | Mississippi |
| United States | HaysMed | Hays | Kansas |
| United States | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania |
| United States | Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania |
| United States | Saint Peter's Community Hospital | Helena | Montana |
| United States | Cancer and Blood Specialists-Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
| United States | GenesisCare USA - Henderson | Henderson | Nevada |
| United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
| United States | Las Vegas Urology - Green Valley | Henderson | Nevada |
| United States | Las Vegas Urology - Pebble | Henderson | Nevada |
| United States | OptumCare Cancer Care at Seven Hills | Henderson | Nevada |
| United States | Urology Specialists of Nevada - Green Valley | Henderson | Nevada |
| United States | AdventHealth Hendersonville | Hendersonville | North Carolina |
| United States | Hendersonville Hematology and Oncology at Pardee | Hendersonville | North Carolina |
| United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
| United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
| United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
| United States | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois |
| United States | South Carolina Cancer Specialists PC | Hilton Head Island | South Carolina |
| United States | The Radiation Oncology Center-Hilton Head/Bluffton | Hilton Head Island | South Carolina |
| United States | Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee |
| United States | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida |
| United States | Bayshore Community Hospital | Holmdel | New Jersey |
| United States | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii |
| United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
| United States | Hawaii Diagnostic Radiology Services LLC | Honolulu | Hawaii |
| United States | Island Urology | Honolulu | Hawaii |
| United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Kuakini Medical Center | Honolulu | Hawaii |
| United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
| United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
| United States | Queen's Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas |
| United States | Mary Bird Perkins Cancer Center - Houma | Houma | Louisiana |
| United States | Oncology Center of The South Incorporated | Houma | Louisiana |
| United States | Terrebonne General Medical Center | Houma | Louisiana |
| United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
| United States | Houston Methodist Hospital | Houston | Texas |
| United States | M D Anderson Cancer Center | Houston | Texas |
| United States | MD Anderson West Houston | Houston | Texas |
| United States | Memorial Hermann Texas Medical Center | Houston | Texas |
| United States | Memorial Hermann Northeast Hospital | Humble | Texas |
| United States | Novant Health Cancer Institute - Huntersville | Huntersville | North Carolina |
| United States | Novant Health Presbyterian Medical Center Huntersville | Huntersville | North Carolina |
| United States | Southern Oncology Specialists-Huntersville | Huntersville | North Carolina |
| United States | Edwards Comprehensive Cancer Center | Huntington | West Virginia |
| United States | Centerpoint Medical Center LLC | Independence | Missouri |
| United States | IRMC Cancer Center | Indiana | Pennsylvania |
| United States | Community Cancer Center East | Indianapolis | Indiana |
| United States | Community Cancer Center North | Indianapolis | Indiana |
| United States | Community Cancer Center South | Indianapolis | Indiana |
| United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
| United States | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana |
| United States | Springmill Medical Center | Indianapolis | Indiana |
| United States | Essentia Health - International Falls Clinic | International Falls | Minnesota |
| United States | Kaiser Permanente-Irvine | Irvine | California |
| United States | Swedish Cancer Institute-Issaquah | Issaquah | Washington |
| United States | Allegiance Health | Jackson | Michigan |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Mayo Clinic in Florida | Jacksonville | Florida |
| United States | Onslow Memorial Hospital | Jacksonville | North Carolina |
| United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
| United States | Essentia Health - Jamestown Clinic | Jamestown | North Dakota |
| United States | Mercyhealth Hospital and Cancer Center - Janesville | Janesville | Wisconsin |
| United States | McFarland Clinic - Jefferson | Jefferson | Iowa |
| United States | MU Health Care Goldschmidt Cancer Center | Jefferson City | Missouri |
| United States | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania |
| United States | Duly Health and Care Joliet | Joliet | Illinois |
| United States | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas |
| United States | Freeman Health System | Joplin | Missouri |
| United States | Mercy Hospital Joplin | Joplin | Missouri |
| United States | Straub Medical Center - Kahului Clinic | Kahului | Hawaii |
| United States | Castle Medical Center | Kailua | Hawaii |
| United States | Borgess Medical Center | Kalamazoo | Michigan |
| United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
| United States | West Michigan Cancer Center | Kalamazoo | Michigan |
| United States | Kalispell Regional Medical Center | Kalispell | Montana |
| United States | Presence Saint Mary's Hospital | Kankakee | Illinois |
| United States | Research Medical Center | Kansas City | Missouri |
| United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
| United States | The University of Kansas Cancer Center-South | Kansas City | Missouri |
| United States | University Health Truman Medical Center | Kansas City | Missouri |
| United States | University of Kansas Cancer Center | Kansas City | Kansas |
| United States | University of Kansas Cancer Center - North | Kansas City | Missouri |
| United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
| United States | CHI Health Good Samaritan | Kearney | Nebraska |
| United States | Heartland Hematology and Oncology | Kearney | Nebraska |
| United States | Maine Center for Cancer Medicine-Kennebunk | Kennebunk | Maine |
| United States | Ochsner Medical Center Kenner | Kenner | Louisiana |
| United States | Kadlec Clinic Hematology and Oncology | Kennewick | Washington |
| United States | Northwest Cancer Clinic | Kennewick | Washington |
| United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
| United States | Novant Health Cancer Institute - Kernersville | Kernersville | North Carolina |
| United States | First Dayton Cancer Care | Kettering | Ohio |
| United States | Greater Dayton Cancer Center | Kettering | Ohio |
| United States | Kettering Medical Center | Kettering | Ohio |
| United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
| United States | Kingman Regional Medical Center | Kingman | Arizona |
| United States | Armstrong Center for Medicine and Health | Kittanning | Pennsylvania |
| United States | Tennessee Cancer Specialists-Dowell Springs | Knoxville | Tennessee |
| United States | Thompson Cancer Survival Center | Knoxville | Tennessee |
| United States | Thompson Cancer Survival Center - West | Knoxville | Tennessee |
| United States | Community Howard Regional Health | Kokomo | Indiana |
| United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
| United States | UC San Diego Moores Cancer Center | La Jolla | California |
| United States | Providence Regional Cancer System-Lacey | Lacey | Washington |
| United States | Marshfield Medical Center - Ladysmith | Ladysmith | Wisconsin |
| United States | Good Samaritan Medical Center | Lafayette | Colorado |
| United States | IU Health Arnett Cancer Care | Lafayette | Indiana |
| United States | Kaiser Permanente-Rock Creek | Lafayette | Colorado |
| United States | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois |
| United States | Northwell Health/Center for Advanced Medicine | Lake Success | New York |
| United States | The Watson Clinic | Lakeland | Florida |
| United States | Monmouth Medical Center Southern Campus | Lakewood | New Jersey |
| United States | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado |
| United States | Saint Anthony Hospital | Lakewood | Colorado |
| United States | Saint Clare Hospital | Lakewood | Washington |
| United States | Fairfield Medical Center | Lancaster | Ohio |
| United States | Lancaster General Ann B Barshinger Cancer Institute | Lancaster | Pennsylvania |
| United States | Lancaster General Hospital | Lancaster | Pennsylvania |
| United States | Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan |
| United States | University of Michigan Health - Sparrow Lansing | Lansing | Michigan |
| United States | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico |
| United States | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada |
| United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada |
| United States | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada |
| United States | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada |
| United States | Desert West Surgery | Las Vegas | Nevada |
| United States | GenesisCare USA - Fort Apache | Las Vegas | Nevada |
| United States | GenesisCare USA - Las Vegas | Las Vegas | Nevada |
| United States | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada |
| United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
| United States | Las Vegas Prostate Cancer Center | Las Vegas | Nevada |
| United States | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada |
| United States | Las Vegas Urology - Pecos | Las Vegas | Nevada |
| United States | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada |
| United States | Las Vegas Urology - Sunset | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Charleston | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at MountainView | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada |
| United States | Summerlin Hospital Medical Center | Las Vegas | Nevada |
| United States | Sunrise Hospital and Medical Center | Las Vegas | Nevada |
| United States | University Medical Center of Southern Nevada | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Central | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada |
| United States | Lawrence Memorial Hospital | Lawrence | Kansas |
| United States | Northside Hospital - Gwinnett | Lawrenceville | Georgia |
| United States | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma |
| United States | MD Anderson League City | League City | Texas |
| United States | Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire |
| United States | Sechler Family Cancer Center | Lebanon | Pennsylvania |
| United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
| United States | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri |
| United States | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas |
| United States | Minimally Invasive Surgery Hospital | Lenexa | Kansas |
| United States | Beebe Medical Center | Lewes | Delaware |
| United States | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania |
| United States | Lewistown Hospital | Lewistown | Pennsylvania |
| United States | Baptist Health Lexington | Lexington | Kentucky |
| United States | Saint Joseph Hospital East | Lexington | Kentucky |
| United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
| United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
| United States | Liberty Radiation Oncology Center | Liberty | Missouri |
| United States | AMG Libertyville - Oncology | Libertyville | Illinois |
| United States | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii |
| United States | Saint Rita's Medical Center | Lima | Ohio |
| United States | Cancer Partners of Nebraska | Lincoln | Nebraska |
| United States | Nebraska Cancer Research Center | Lincoln | Nebraska |
| United States | Nebraska Hematology and Oncology | Lincoln | Nebraska |
| United States | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska |
| United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
| United States | Littleton Adventist Hospital | Littleton | Colorado |
| United States | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado |
| United States | Saint Barnabas Medical Center | Livingston | New Jersey |
| United States | Hope Cancer Clinic | Livonia | Michigan |
| United States | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan |
| United States | Logan Regional Hospital | Logan | Utah |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | Saint Joseph London | London | Kentucky |
| United States | Kaiser Permanente-Lone Tree | Lone Tree | Colorado |
| United States | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado |
| United States | Sky Ridge Medical Center | Lone Tree | Colorado |
| United States | Monmouth Medical Center | Long Branch | New Jersey |
| United States | Longmont United Hospital | Longmont | Colorado |
| United States | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado |
| United States | PeaceHealth Saint John Medical Center | Longview | Washington |
| United States | Cedars Sinai Medical Center | Los Angeles | California |
| United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
| United States | Kaiser Permanente West Los Angeles | Los Angeles | California |
| United States | Los Angeles General Medical Center | Los Angeles | California |
| United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
| United States | Baptist Health Louisville | Louisville | Kentucky |
| United States | Jewish Hospital | Louisville | Kentucky |
| United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
| United States | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky |
| United States | UofL Health Medical Center Northeast | Louisville | Kentucky |
| United States | Banner McKee Medical Center | Loveland | Colorado |
| United States | Lowell General Hospital | Lowell | Massachusetts |
| United States | Covenant Medical Center-Lakeside | Lubbock | Texas |
| United States | Centra Alan B Pearson Regional Cancer Center | Lynchburg | Virginia |
| United States | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington |
| United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
| United States | Illinois CancerCare-Macomb | Macomb | Illinois |
| United States | Michigan Breast Specialists-Macomb Township | Macomb | Michigan |
| United States | Atrium Health Navicent | Macon | Georgia |
| United States | Central Georgia Gynecologic Oncology | Macon | Georgia |
| United States | University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin |
| United States | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky |
| United States | Southern Ocean County Medical Center | Manahawkin | New Jersey |
| United States | Dartmouth Cancer Center - Manchester | Manchester | New Hampshire |
| United States | Elliot Hospital | Manchester | New Hampshire |
| United States | Solinsky Center for Cancer Care | Manchester | New Hampshire |
| United States | North Shore University Hospital | Manhasset | New York |
| United States | Holy Family Memorial Hospital | Manitowoc | Wisconsin |
| United States | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota |
| United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
| United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
| United States | Marietta Memorial Hospital | Marietta | Ohio |
| United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin |
| United States | OhioHealth Marion General Hospital | Marion | Ohio |
| United States | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan |
| United States | West Jefferson Medical Center | Marrero | Louisiana |
| United States | McFarland Clinic - Marshalltown | Marshalltown | Iowa |
| United States | Marshfield Medical Center | Marshfield | Wisconsin |
| United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
| United States | Contra Costa Regional Medical Center | Martinez | California |
| United States | WVUH-Berkely Medical Center | Martinsburg | West Virginia |
| United States | Sovah Health Martinsville | Martinsville | Virginia |
| United States | Fremont - Rideout Cancer Center | Marysville | California |
| United States | Thompson Oncology Group-Maryville | Maryville | Tennessee |
| United States | Matthews Radiation Oncology Center | Matthews | North Carolina |
| United States | Novant Health Cancer Institute - Matthews | Matthews | North Carolina |
| United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
| United States | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio |
| United States | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio |
| United States | UH Seidman Cancer Center at Landerbrook Health Center | Mayfield Heights | Ohio |
| United States | Loyola University Medical Center | Maywood | Illinois |
| United States | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania |
| United States | Redeemer Health | Meadowbrook | Pennsylvania |
| United States | UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania |
| United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
| United States | Aspirus Medford Hospital | Medford | Wisconsin |
| United States | Riddle Memorial Hospital | Media | Pennsylvania |
| United States | Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois |
| United States | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee |
| United States | Family Cancer Center-Memphis | Memphis | Tennessee |
| United States | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio |
| United States | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin |
| United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
| United States | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho |
| United States | East Jefferson General Hospital | Metairie | Louisiana |
| United States | Robert Veith MD LLC | Metairie | Louisiana |
| United States | Miami Cancer Institute | Miami | Florida |
| United States | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida |
| United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
| United States | Mount Sinai Medical Center | Miami Beach | Florida |
| United States | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana |
| United States | Woodland Cancer Care Center | Michigan City | Indiana |
| United States | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio |
| United States | Dayton Physicians LLC-Signal Point | Middletown | Ohio |
| United States | Memorial Sloan Kettering Monmouth | Middletown | New Jersey |
| United States | MyMichigan Medical Center Midland | Midland | Michigan |
| United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
| United States | Bon Secours Westchester Emergency Center | Midlothian | Virginia |
| United States | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin |
| United States | Ascension Saint Francis Hospital | Milwaukee | Wisconsin |
| United States | Ascension Southeast Wisconsin Hospital - Saint Joseph Campus | Milwaukee | Wisconsin |
| United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
| United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
| United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
| United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
| United States | Health Partners Inc | Minneapolis | Minnesota |
| United States | Hennepin County Medical Center | Minneapolis | Minnesota |
| United States | University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota |
| United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
| United States | Trinity Cancer Care Center | Minot | North Dakota |
| United States | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana |
| United States | Michiana Hematology Oncology PC-Mishawaka | Mishawaka | Indiana |
| United States | Community Medical Center | Missoula | Montana |
| United States | Saint Patrick Hospital - Community Hospital | Missoula | Montana |
| United States | Mobile Infirmary Medical Center | Mobile | Alabama |
| United States | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama |
| United States | Kaiser Permanente-Modesto | Modesto | California |
| United States | Memorial Medical Center | Modesto | California |
| United States | Trinity Medical Center | Moline | Illinois |
| United States | Monroe Cancer Center | Monroe | Michigan |
| United States | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana |
| United States | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan |
| United States | Forbes Hospital | Monroeville | Pennsylvania |
| United States | UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania |
| United States | Community Hospital of Monterey Peninsula | Monterey | California |
| United States | Pacific Cancer Care-Monterey | Monterey | California |
| United States | Monticello Cancer Center | Monticello | Minnesota |
| United States | UPMC Hillman Cancer Center in Coraopolis | Moon | Pennsylvania |
| United States | Novant Health Cancer Institute - Mooresville | Mooresville | North Carolina |
| United States | Essentia Health - Moose Lake Clinic | Moose Lake | Minnesota |
| United States | Monongalia Hospital | Morgantown | West Virginia |
| United States | West Virginia University Healthcare | Morgantown | West Virginia |
| United States | Morristown Medical Center | Morristown | New Jersey |
| United States | Novant Health Cancer Institute - Mount Airy | Mount Airy | North Carolina |
| United States | Lowcountry Hematology Oncology PA-Mount Pleasant | Mount Pleasant | South Carolina |
| United States | UPMC Hillman Cancer Center - Part of Frick Hospital | Mount Pleasant | Pennsylvania |
| United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
| United States | Knox Community Hospital | Mount Vernon | Ohio |
| United States | Skagit Regional Health Cancer Care Center | Mount Vernon | Washington |
| United States | Skagit Valley Hospital | Mount Vernon | Washington |
| United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
| United States | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California |
| United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
| United States | Inspira Medical Center Mullica Hill | Mullica Hill | New Jersey |
| United States | Intermountain Medical Center | Murray | Utah |
| United States | Trinity Health Muskegon Hospital | Muskegon | Michigan |
| United States | Arnold Palmer Cancer Center Medical Oncology Norwin | N. Huntingdon | Pennsylvania |
| United States | Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho |
| United States | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho |
| United States | Edward Hospital/Cancer Center | Naperville | Illinois |
| United States | Dartmouth Cancer Center - Nashua | Nashua | New Hampshire |
| United States | Meharry Medical College | Nashville | Tennessee |
| United States | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee |
| United States | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee |
| United States | Allegheny Valley Hospital | Natrona Heights | Pennsylvania |
| United States | UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania |
| United States | Jersey Shore Medical Center | Neptune | New Jersey |
| United States | Baptist Health Floyd | New Albany | Indiana |
| United States | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi |
| United States | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey |
| United States | UPMC Hillman Cancer Center - New Castle | New Castle | Pennsylvania |
| United States | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut |
| United States | Yale University | New Haven | Connecticut |
| United States | Long Island Jewish Medical Center | New Hyde Park | New York |
| United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
| United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
| United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
| United States | Tulane University School of Medicine | New Orleans | Louisiana |
| United States | University Medical Center New Orleans | New Orleans | Louisiana |
| United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
| United States | New Ulm Medical Center | New Ulm | Minnesota |
| United States | Lenox Hill Hospital | New York | New York |
| United States | Manhattan Eye Ear and Throat Hospital | New York | New York |
| United States | Memorial Sloan Kettering Cancer Center | New York | New York |
| United States | Mount Sinai Hospital | New York | New York |
| United States | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York |
| United States | NYP/Weill Cornell Medical Center | New York | New York |
| United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
| United States | Christiana Gynecologic Oncology LLC | Newark | Delaware |
| United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
| United States | Helen F Graham Cancer Center | Newark | Delaware |
| United States | Licking Memorial Hospital | Newark | Ohio |
| United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
| United States | Newark Beth Israel Medical Center | Newark | New Jersey |
| United States | Newark Radiation Oncology | Newark | Ohio |
| United States | Providence Newberg Medical Center | Newberg | Oregon |
| United States | Chancellor Center for Oncology | Newburgh | Indiana |
| United States | CTCA at Southeastern Regional Medical Center | Newnan | Georgia |
| United States | Newport Hospital | Newport | Rhode Island |
| United States | USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California |
| United States | Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan |
| United States | Children's Hospital of The King's Daughters | Norfolk | Virginia |
| United States | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska |
| United States | Suburban Community Hospital and Cancer Center | Norristown | Pennsylvania |
| United States | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut |
| United States | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri |
| United States | Great Plains Health Callahan Cancer Center | North Platte | Nebraska |
| United States | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan |
| United States | Stephens Memorial Hospital | Norway | Maine |
| United States | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut |
| United States | Sutter Cancer Research Consortium | Novato | California |
| United States | Ascension Providence Hospitals - Novi | Novi | Michigan |
| United States | Henry Ford Medical Center-Columbus | Novi | Michigan |
| United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
| United States | Thompson Oncology Group-Oak Ridge | Oak Ridge | Tennessee |
| United States | Alta Bates Summit Medical Center - Summit Campus | Oakland | California |
| United States | Bay Area Tumor Institute | Oakland | California |
| United States | Kaiser Permanente Oakland-Broadway | Oakland | California |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | Health Central | Ocoee | Florida |
| United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
| United States | McKay-Dee Hospital Center | Ogden | Utah |
| United States | Integris Cancer Institute of Oklahoma | Oklahoma City | Oklahoma |
| United States | Integris Southwest Medical Center | Oklahoma City | Oklahoma |
| United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Olathe Health Cancer Center | Olathe | Kansas |
| United States | MedStar Montgomery Medical Center | Olney | Maryland |
| United States | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska |
| United States | Alegent Health Immanuel Medical Center | Omaha | Nebraska |
| United States | Alegent Health Lakeside Hospital | Omaha | Nebraska |
| United States | Creighton University Medical Center | Omaha | Nebraska |
| United States | Hematology and Oncology Consultants PC | Omaha | Nebraska |
| United States | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska |
| United States | Nebraska Cancer Specialists/Oncology Hematology West PC - MECC | Omaha | Nebraska |
| United States | Nebraska Medicine-Village Pointe | Omaha | Nebraska |
| United States | Nebraska Methodist Hospital | Omaha | Nebraska |
| United States | Oncology Associates PC | Omaha | Nebraska |
| United States | Oncology Hematology West PC | Omaha | Nebraska |
| United States | University of Nebraska Medical Center | Omaha | Nebraska |
| United States | Kaiser Permanente-Ontario | Ontario | California |
| United States | Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon |
| United States | Memorial GYN Plus | Ooltewah | Tennessee |
| United States | Saint Joseph Hospital - Orange | Orange | California |
| United States | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut |
| United States | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California |
| United States | Saint Charles Hospital | Oregon | Ohio |
| United States | Providence Willamette Falls Medical Center | Oregon City | Oregon |
| United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
| United States | Orlando Health Cancer Institute | Orlando | Florida |
| United States | Ascension Mercy Hospital | Oshkosh | Wisconsin |
| United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
| United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
| United States | Radiation Oncology of Northern Illinois | Ottawa | Illinois |
| United States | Ottumwa Regional Health Center | Ottumwa | Iowa |
| United States | Menorah Medical Center | Overland Park | Kansas |
| United States | Saint Luke's South Hospital | Overland Park | Kansas |
| United States | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas |
| United States | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi |
| United States | Baptist Health Paducah | Paducah | Kentucky |
| United States | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada |
| United States | Desert Regional Medical Center | Palm Springs | California |
| United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
| United States | Stanford Cancer Institute Palo Alto | Palo Alto | California |
| United States | VA Palo Alto Health Care System | Palo Alto | California |
| * Note: There are 1432 locations in all - only the first 1000 are shown. | |||
| Lead Sponsor | Collaborator |
|---|---|
| National Cancer Institute (NCI) |
United States, Guam, Puerto Rico,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Objective response rate (ORR) | ORR is defined as the percentage of patients whose tumors have a complete or partial response to treatment among analyzable patients. Objective response is defined consistent with Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. 90% two-sided confidence interval is calculated for ORR. For the purposes of this study, patients should be re-evaluated for response:
For treatments given in 21 day (3 week) cycles: every 3 cycles (9 weeks) for the first 33 cycles, and every 4 cycles thereafter (12 weeks) For treatments given in 28 day (4 week) cycles: every 2 cycles (8 weeks) for the first 26 cycles, and every three cycles thereafter (12 weeks) For treatments given in 42 day (6 week) cycles: every 2 cycles (12 weeks) |
Up to 3 years | |
| Secondary | Overall survival (OS) | Will be evaluated specifically for each drug (or step). OS will be estimated using the Kaplan-Meier method. | From start of treatment on that step until death, or censored at the date of last contact, assessed up to 3 years | |
| Secondary | 6-month progression free survival (PFS) rate | Progression free survival is defined as time from treatment start date to date of progression or death from any cause, whichever occurs first. Disease progression was evaluated using the Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. Please refer to the protocol for detailed definitions of disease progression. 6 month PFS rate was estimated using the Kaplan-Meier method, which can provide a point estimate for any specific time point. | From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed at 6 months | |
| Secondary | Progression free survival | PFS was defined as time from treatment start date to date of disease progression or death from any causes, whichever occurred first. Median PFS was estimated using the Kaplan-Meier method. Disease progression was evaluated using the Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. Please refer to the protocol for detailed definitions of disease progression. | From start of treatment on that step until determination of disease progression or death from any cause, censored at the date of last disease assessment for patients who have not progressed, assessed up to 3 years |
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|
N/A | |
| Active, not recruiting |
NCT03844048 -
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
|
Phase 3 | |
| Recruiting |
NCT03412877 -
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
|
Phase 2 | |
| Completed |
NCT02916979 -
Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG
|
Phase 1 | |
| Recruiting |
NCT03570983 -
A Trial Comparing Single Agent Melphalan to Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) as a Preparative Regimen for Patients With Multiple Myeloma Undergoing High Dose Therapy Followed by Autologous Stem Cell Reinfusion
|
Phase 2 | |
| Completed |
NCT03665155 -
First-in- Human Imaging of Multiple Myeloma Using 89Zr-DFO-daratumumab, a CD38-targeting Monoclonal Antibody
|
Phase 1/Phase 2 | |
| Terminated |
NCT03399448 -
NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells)
|
Phase 1 | |
| Completed |
NCT02812706 -
Isatuximab Single Agent Study in Japanese Relapsed AND Refractory Multiple Myeloma Patients
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT05024045 -
Study of Oral LOXO-338 in Patients With Advanced Blood Cancers
|
Phase 1 | |
| Active, not recruiting |
NCT03792763 -
Denosumab for High Risk SMM and SLiM CRAB Positive, Early Myeloma Patients
|
Phase 2 | |
| Active, not recruiting |
NCT03989414 -
A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
|
Phase 1/Phase 2 | |
| Withdrawn |
NCT03608501 -
A Study of Ixazomib, Thalidomide and Dexamethasone in Newly Diagnosed and Treatment-naive Multiple Myeloma (MM) Participants Non-eligible for Autologous Stem-cell Transplantation
|
Phase 2 | |
| Recruiting |
NCT04537442 -
Clinical Study to Evaluate the Safety and Efficacy of IM21 CAR-T Cells in the Treatment of Elderly Patients With Relapsed or Refractory Multiple Myeloma
|
Phase 1 | |
| Completed |
NCT02546167 -
CART-BCMA Cells for Multiple Myeloma
|
Phase 1 |