Multiple Myeloma Clinical Trial
Official title:
Prospective Follow-up of Relapse Myeloma Patients After Previous Exposure to Bortezomib and Lenalidomide Treated on Pomalidomide and Dexamethasone
Asian patients with relapsed myeloma after prior treatment with bortezomib and lenalidomide
will treatment on pomalidomde and dexamethasone.
Baseline, follow-up, survival and toxicity information will be collected.
Myeloma patients who relapse after prior treatment with bortezomib and lenalidomide have
survival of less than 1 year. Recently, a randomized study of Pomalidomide and dexamethasone
conducted in compared with placebo and dexamethasone showed that pomalidomide can improve
survival of this group of patients.
Pomalidomide is a new immunomodulatory drug which has been shown to be active in myeloma
patients who relapse after bortezomib and lenalidomide. A recent phase III study comparing
pomalidomide plus dexamethasone with placebo plus high dose dexamethasone in patients with
prior exposure to bortezomib and lenalidomide, showed that the use of pomalidomide
significantly improve the overall survival of these patients. However, this study did not
include Asian patients. Therefore the efficacy and toxicity of pomalidomide remains to be
described in Asian patients
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